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2024Yoshizato, R., Miura, M., Shitaoka, K., Matsuoka, Y., Higashiura, A., Yamamoto, A, Guo, Y.,Azuma, H.,Kawano, Y., Ohga,S. and Yasuda,T. Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten. Heliyon 10(23): e40837, 2024. doi: 10.1016/j.heliyon.2024.e40837 Rebun, K.,Sakaguchi, T. and Aoyama, H. Origin of autopsy bodies used in medical and dental education Hiroshima University in Japan after World War II. Hiroshima Journal of Medical Sciences, in press. 西本奈未，丹羽智瑛，森田智子，佐々木裕明，Abeer Mohamed Abdelfattah Elsayed，進藤智弘，山里圭，坂口剛正 各種細菌・真菌および病原ウイルスに対するエタノールを有効成分とする医薬部外品「フマキラー消毒C1」の有効性判定 医学と薬学, in press. Kumamoto, S., Yamamoto, A., Shiratsuchi, Y., Matsuo, K.,Higashiura, A., Hira, D. Structural Investigations of Cargo Molecules Inside Icosahedrally Symmetric Encapsulin by VUVCD Spectroscopic Measurements.Chirality 36(8): e23700, 2024. doi: 10.1002/chir.23700 Kurose, M., Morita, T., Yoshimoto, R., Elsayed, A. M. A., Lawal-Ayinde, B. M., Nomura, Y., Irie, T., Fukushi, M., Kanda, M., Tahara, H., Ko Ko, Takahashi, K., Tanaka, J. and Sakaguchi, T. Viral coexistence and insertional mutations in the ORF8 region of SARS-CoV-2: a possible mechanism of nucleotide insertion. Virus Research 350:199478, 2024. doi: 10.1016/j.virusres.2024.199478. 東浦彰史, 山本旭麻, 坂口剛正, 保田朋波流 SARS CoV-2スパイク蛋白質と各種中和抗体の複合体構造解析より明らかとなった中和活性の構造的基盤 日本結晶学会誌 66(2):115-120, 2024.ISSN 1884-5576, Print ISSN 0369-4585, https://doi.org/10.5940/jcrsj.66.115 Sukmana, N. C., Sugiarto, Shinogi, J., Kojima, T., Fujibayashi, M., Inoue, K., Nishihara, S., Cao, Y., Zhu, T., Ubukata, H., Higashiura, A., Yamamoto, A., Tassel, C., Kageyama, H., Sakaguchi, T., Sadakane, M. Structure Transformation of Methylammonium Polyoxomolybdates via In-Solution Acidification and Solid-State Heating of Methylammonium Monomolybdate and their Application as Negative Staining Reagents for Coronavirus Observation. Inorganic Chemistry,63(22):10207-10220,2024. Suzuki, Y., Kawada-Matsuo, M., Le, M., Eng, S. S., Hisatsune, J., Sugai, M., Sakaguchi, T., and Komatsuzawa, H. The two-component regulatory systems GraRS and SrrAB mediate Staphylococcus aureus susceptibility to Pep5 produced by clinical isolate of Staphylococcus epidermidis. Applied and Environmental Microbiology, the section Genetics and Molecular Biology, e0030024. doi:10.1128/aem.00300-24 Nikawa, H. and Sakaguchi, T. Development of Etak, an ethoxysilane-based immobilized antibacterial and antiviral agent. Biomedical Engineering, 1st ed., p. 404, Miyauchi, A. and Kagechika, H. eds, Jenny Stanford Publishing, New York. doi:10.1201/9781003464044, ISBN-10: 9815129163, ISBN-13: 978-9815129168 Iwata, M., Kawabata, R., Morimoto, N., Takeuchi, R. F., Sakaguchi, T., Irie, T. and Osakada, F. Evolutionary Engineering and Characterization of Sendai Virus Mutants Capable of Persistent Infection and Autonomous Production. Front. Virol., Volume 4, 2024. https://doi.org/10.3389/fviro.2024.1363092 Tanaka, H., Miyagi, S., Morita, T., Oishi, K., Mori, N., Sakaguchi, T. and Usuki, T. Synthesis and Cell-Based Evaluation of Umifenovir Analogues as Anti-SARS-CoV-2 Agents. Helvetica Chimica Acta, doi: 10.1002/hlca.202300208 Kakimoto M, Nomura T, Nazmul T, Yamamoto A, Sasaki H, Higashiura A, Ito M, Ohge H, Mikage M, Ochiai-Ogawa K, and Sakaguchi T. In vitro anti-severe acute respiratory syndrome coronavirus 2 effect of Ephedra przewalskii Stapf extract. Journal of Ethnopharmacology 319 (Pt3): 117341, 2023. doi: 10.1016/j.jep.2023.117341. Online ahead of print on 2023/10/23 Sakuda, T., Oda, A., Furuta, T., Johan, M. P., Sakaguchi, T., and Adachi, N. Synergistic VSV virotherapy and carbon nanotube photothermal therapy for osteosarcoma in murine models. Anticancer Research 44(1): 99-105, 2024. doi: 10.21873/anticanres.16792 2023坂口剛正 かなり強力！ 柿渋のウイルス退治効果、「柿暮らし」 2023現代農業別冊 pp. 56-57 一般社団法人 農山漁村文化協会 Lawal-Ayinde, B. M., Morita, T.,Oda, K.Nazmul, T., Kurose, M., Nomura, T., Yamamoto, A., Higashiura, A., Akita, T.,Tanaka, J., Horiuchi, I., Goda, H., and Sakaguchi, T. Virus purification highlights high susceptibility of SARA-CoV-2 to a chlorine-based disinfectant, chlorous acid. PLOS ONE 18(7): e0288634,2023. Doi: 10.1371/journal.pone.0288634 Ishitoku, M., Mokuda, S., Araki, K., Watanabe, H., Kohno, H., Sugimoto,T., Yoshida, Y., Sakaguchi, T., Masumoto, J., Hirata, S., Sugiyama, E. Tumor necrosis factor and interleukin -1β upregulate NRP2 expression and promote SARS-CoV-2 proliferation. Viruses 15,1498. Doi: 10.3390/ v15071498 山岡弘二、高尾信一、野村俊二、Tanuza Nazmul、坂口剛正 広島県動物感染症サーベイランスシステムと重症熱性血小板減少症候群(SFTS)の発生状況 広島県獣医学会雑誌 No.37,pp.75-79, 2023 Nazmul,T., Lawal-Ayinde, B. M., Morita, T., Yoshimoto, R., Higashiura, A., Yamamoto, A., Nomura, T., Nakano, Y., Hirayama, M., Kurokawa , H., Kitamura,Y., Hori, K., and Sakaguchi,T. Capture and neutralization of SARS-CoV-2 and influenza virus by algae-derived lectins with high-mannose and core fucose specificities. Microbiology and Immunology 67(7): 334-344, 2023. Doi:10.1111/ 1348-0421.13082, Online ahead of print. May 29, 2023. Fukushi, M.,Ohsawa, R., Okinaka, Y., Oikawa, D., Kiyono, T., Masaya Moriwaki, M., Irie, T., Oda, K., Kamei, Y., Tokunaga, F., Sotomaru, Y., Maruyama, H., Kawakami, H., and Sakaguachi, T. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection. PLOS ONE, 18(6):e0287545. Doi: 101371/journal.pone.0287545 Shitaoka, K., Higashiura, A., Kawano, Y., Yamamoto A., Mizoguchi, Y., Hashiguchi, T., Nishimichi, N., Huang, S., Ito, A., Ohki, S., Kanda, M., Taniguchi, T., Yokosaki, Y., Okada, S., Sakaguchi, T. and Yasuda, T. Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants. Communications Biology 6:395, 2023, doi: 10.1038/s42003-023-04782-6. Sukmana, N. C., Sugiarto, Shinogi, J., Kojima, T., Higashiura, A., Yamamoto, A., Sakaguchi, T., and Sadakane, M. Solid-State Thermal Transformation of Methylammonium Mono-Molybdate to Isopolymolybdates and their application as Staining Reagents for TEM observation of Viruses. Chemistry Letters 52:167-171,2023. doi:10.1246/ cl.2205156.. 坂口剛正 焦点「日本のワクチン」 広島市医師会だより 令和5年3月号 No.683 pp. 6-10. Sakuda, T., Kubo, T., Johan, M. P., Furuta, T., Sakaguchi, T., and Adachi, N. Oncolytic effect of a recombinant vesicular stomatitis virus encoding a tumor-suppressor microRNA in an osteosarcoma mouse model. Anticancer Research 43: 2023. doi: 10.21873/anticanres.16264 . 坂口剛正, 黒瀬美羽子, 東浦彰史, 山本旭麻 第3章 今後の創薬への活用：感染症ワクチン 第1節 新型コロナウイルスの増殖機構・病原性発現機構 pp. 215-223. 技術情報協会 書籍「mRNAの制御機構の解明と治療薬・ワクチンへの活用」 ISBN 978-4-86104-937-8 C3047 総頁数411頁 Kitagawa, H., Nomura, T., Kaiki, Y., Kakimoto, M., Nazmul, T., Omori, K., Shigemoto, N., Sakaguchi, T., Ohge, H. Viable SARS-CoV-2 detected in the air of hospital rooms of COVID-19 patients with early infection. International Journal of Infectious Diseases (Int. J. Infect. Dis.), 126:73-78, 2023. doi: 10.1016/j.ijid.2022.11.003. 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Inhibiting SARS-CoV-2 infection by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal. Scientifc Reports 11:16629, 2021. 坂口剛正 用語解説シリーズ「抗体依存性増強」アレルギー 70(5):394-395, 2021. Shinji, K., Chikama, T., Okazaki, S., Uto, Y., Sueoka, K., Pertiwi, Y. D., Ko, J.-A., Kiuchi, Y., and Sakaguchi, T. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue. Journal of Photochemistry & Photobiology, B: Biology 221:112239, 2021. 木全基樹、鈴木智美、二川浩樹、坂口剛正 持続型抗菌成分 Octadecyl dimethyl(3-triethoxysilylpropyl) ammonium chlorideの新型コロナウイルス（SARS-CoV-2）への抗ウイルス効果 医学と薬学 78(6):767-776, 2021. 坂口剛正、東浦彰史 界面活性剤による抗ウイルス作用メカニズム「抗ウイルス・抗菌製品開発 〜基礎、作用メカニズムから評価、認証、商品化まで〜」117〜123頁 松村吉信(監修) 第２編第２章第３節 株式会社エヌ・ティー・エス 2021年3月30日発刊 Kitagawa, H., Nomura, T., Nazmul, T., Kawano, R., Omori, K., Shigemoto, N., Sakaguchi, T., and Ohge, H. Effect of intermittent irradiation and dose-response of 222 nm ultraviolet light on SARS-CoV-2 contamination. Photodiagnosis and Photodynamic Therapy 33:102184, 2021. Kitagawa, H., Nomura, T., Ohge, H., Nazmul, T., Omori, K., Shigemoto, N., and Sakaguchi, T. Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination. Am. J. Infect. Control. 49(3):299-301, 2021. doi:10.1016/j.ajic.2020.08.022. 坂口剛正、長岡里枝、樫山誠也、山崎真一、横崎典哉、大瀬塁 コバスPCRメディアの使用によるSARS-CoV-2不活化の検討 医学と薬学 78(3):275-280, 2021. 片岡 健「天然せっけんで新型コロナがほぼ不活化〜北九州市の企業との共同研究により確認（前、後）」坂口剛正（監修）Webサイト『NETIB-NEWS』、雑誌「IB アイ・ビー」10-11頁 2021年3月12日公開 中西真理「今だから、きちんと知りたい。新型コロナウイルス感染症のこと」坂口剛正（監修）子育てマガジンFunFANFun春号 ガリバープロダクツ 2021年3月5日発行 中西真理「新型コロナウイルス感染症から、自分と家族を守りましょう」坂口剛正（監修）女性の役に立つ広島ホスピタルガイド2021年版 ガリバープロダクツ 2021年2月22日発行 吉山裕規、東浦彰史、丁丹、飯笹久、坂口剛正 新型コロナウイルスの特徴、感染様式 耳鼻咽喉科・頭頸部外科 93(2):102-107, 2021 2021年2月号 Ko Ko, Nagashima, S., Bunthen, E., Serge, O., Akita, T., Sugiyama, A., Ohisa, M., Sakaguchi, T.., Tahara, H., Ohge, H., Ohdan, H., Kubo, T., Kishita, E., Kuwabara, M., Takahashi, K., and Tanaka, J. Molecular Characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan. PLOS ONE 16(2):e0246383, 2021. 坂口剛正、秋葉勇、東浦彰史 手洗い石けん―ウイルスへの効果を踏まえた賢い選択 感染対策ICTジャーナル 16(1):58-63, 2021 (2021年1月15日発行) 2020坂口剛正 霞キャンパスが考える新型コロナウイルス感染症 〜P3実験室におけるSARS-CoV-2研究〜 広仁会報99号 令和2年12月 12〜13頁 Pertiwi, D. P., Chikama, T., Sueoka, K., Ko, J.-A., Kiuchi, Y., Onodera, M., Sakaguchi, T. Efficacy of photodynamic antimicrobial chemotherapy on Acanthamoeba keratitis in vivo. Lasers in Surgery and Medicine, doi: 10.1002/lsm.23355. 坂口剛正 広島大学の新型コロナウイルス研究 Activities 研究科の活動 Hiroshima University BioMed News 第4号 2020年11月 3ページ 坂口剛正（監修)「病気の原因になるウイルスを運ぶ「飛まつ」」小学保健ニュース No.1247号 2020年11月 少年写真新聞社 坂口剛正（監修)「マスクの効果を高める方法」中学保健ニュース No.1794号 2020年9月 少年写真新聞社 SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant. Konno, Y., Kimura, I., Uriu, K., Fukushi, M., Irie, T., Koyanagi, Y., Sauter, D., Gifford, R. J; USFQ-COVID19 Consortium, Nakagawa, S., and Sato, K. Cell Rep. 32:108185, 2020. doi:10.1016/j.celrep.2020.108185. 桑原正雄、大毛宏喜、坂口剛正、高蓋寿朗、加藤雅史 新型コロナウイルス感染症座談会 第1波を振り返り、第2波に向けて 広島県医師協だより No.598、2020年8月号別冊 天野 篤, 石井さとこ, 奥村 康, 工藤孝文, 坂口剛正, 鈴木克彦, 中村康宏 (監修) 医者が教える免疫力を上げるワザ Power Mook 28 株式会社大洋図書 2020年7月17日 坂口剛正（監修) ウイルスに勝つ！毎日免疫力アップカレンダー 月刊「からだにいいこと」2020年8月号、2020年6月16日発売 豊田圭美「研究者に聞いた、手洗いと固形石鹸の気になる3つのこと」坂口剛正（監修) ラッシュ公式サイト Lush Fresh Handmade Cosmetics 2020年6月15日公開 「コロナにも？ 自然素材石けんは合成洗剤の「1000倍のウイルス破壊力」山根一眞の「科学者を訪ねて三千里」ブルーバックスウェブサイト 坂口剛正（取材協力) 2020年5月1日公開 「コロナ対策の手洗いに期待！「昔ながらの石けん」の抗ウイルス効果」山根一眞の「科学者を訪ねて三千里」ブルーバックスウェブサイト 坂口剛正（取材協力) 2020年4月17日公開 坂口剛正 新しい疫病の出現 新型コロナウイルス 広島市医師会だより 令和2年4月号 No.648 pp.7-11, 2020 入江崇、酒井宏治、坂口剛正 特異なセンダイウイルスクローンの単離とワクチンアジュバントとしての利用 BIO Clinica 35:78-81, 2020 Oikawa, D., Sato, Y., Ohtake, F., Komakura, K., Hanada, K., Sugawara, K., Terawaki, S., Mizukami, Y., Phuong, H. T., Iio, K., Obika, S., Fukushi, M., Irie, T., Tsuruta, D., Sakamoto, S., Tanaka, K., Saeki, Y., Fukai, S., and Tokunaga, F. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.Commun Biol. 3: 163, 2020. doi: 10.1038/s42003-020-0882-8. 2019Nomura, T., Fukushi, M., Oda, K., Higashiura, A., Irie, T., and Sakaguchi, T. Effects of traditional Kampo drugs and their constituent crude drugs on influenza virus replication in vitro: suppression of viral protein synthesis by Glycyrrhizae radix. Evidence-Based Complementary and Alternative Medicine, vol. 2019, Article ID 3230906, 2019. doi: 10.1155/2019/3230906. Pertiwi, Y. D., Sueoka, K., Ko, J.-A., Kiuchi, Y., Onodera, M., and Sakaguchi, T. Photodynamic antimicrobial chemotherapy with the photosensitizer TONS504 eradicates Acanthamoeba. Photodiagnosis and Photodynamic Therapy, 28:166-171, 2019. doi: 10.1016/j.pdpdt.2019.08.035. Irie, T., Sakai, K., and Sakaguchi, T. Development of new concept viral vectors exerting both vaccine and adjuvant activities. Impact Vol. 2019(7): 9-11, 2019. doi: 10.21820/23987073.2019.7.9 Sakuda, T., Kubo, T., Johan, M. P., Furuta, T., Sakaguchi, T., Nakanishi, M., Ochi, M., and Adachi, N. Novel near-infrared fluorescence-guided surgery with vesicular stomatitis virus for complete surgical resection of osteosarcomas in mice. Journal of Orthopaedic Research, 37:1192-1201, 2019. doi: 10.1002/jor.24277. 坂口剛正、入江崇、小田康祐 センダイウイルスがインターフェロンに対抗する仕組み 日本ウイルス学会北海道支部会報 第50巻 2019年1月 入江崇、酒井宏治、坂口剛正 ウイルスベクターワクチンの現状と展望 BIO Clinica 34:107-111, 2019 2018Sueoka, K., Chikama, T., Pertiwi, Y. D., Ko, J.-A., Kiuchi, Y., Sakaguchi, T., and Obana, A. Antifungal efficacy of photodynamic therapy with TONS504 for pathogenic filamentous fungi. Lasers in Medical Science 34:743-747, 2019. doi: 10.1007/s10103-018-2654-y. [Epub ahead of print]. Nakamichi, Y.*, Miyazaki, N.*, Tsutsumi, K.*, Higashiura, A.*, Narita, H., Murata, K., Nakagawa, A. An assembly intermediate structure of Rice dwarf virus reveals a hierarchical outer capsid shell assembly mechanism. Structure, in press, *equal contribution Kawahara, T., Akiba, I., Sakou, M., Sakaguchi, T., and Taniguchi, H. Inactivation of human and avian influenza viruses by electrostatic interaction between virus and the natural soap component potassium oleate. PLOS ONE 13: e0204908, 2018. doi: 10.1371/journal.pone.0204908. Ohmine, T., Narai, S., Matsubara, T., Nomura, T., Oda, K., Fukushi, M., Irie, T., Komatsu, T., Tohya, Y., and Sakaguchi, T. Eligibility of feline calicivirus for a surrogate of human norovirus in comparison with murine norovirus, poliovirus and coxsackievirus. Biocontrol Science 23:145-149, 2018. Moriyama, M., Igarashi, M., Koshiba, T., Irie, T., Takada, A., and Ichinohe, T. Two conserved amino acids within the NSs of SFTS phlebovirus are essential for anti-interferon activity. J Virol. 92: e00706-18, 2018. doi: 10.1128/JVI.00706-18. Johan, M. P., Kubo, T., Furuta, T., Sakuda, T., Sakaguchi, T., Nakanishi, M., and Adachi, M. Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma. Journal of Orthopaedic Research 6:2562-2569, 2018. doi: 10.1002/jor.23911. Sueoka, K., Chikama, T., Latief, M. A., Ko, J.-A., Kiuchi, Y., Sakaguchi, T., and Obana, A. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa. Lasers in Medical Science 33:1455-1460, 2018. doi: 10.1007/s10103-018-2490-0. Tsukamoto, Y., Ikeda, S., Uwai, K., Taguchi, R., Chayama, K., Sakaguchi, T., Narita, R., Yao W.-L., Takeuchi, F., Otakaki, Y., Watashi, K., Wakita, T., Kato, H., and Fujita, T. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. PLOS ONE 13: e0197664, 2018, doi: 10.1371/journal.pone.0197664. Yamamoto, K., Higashiura, A., Huriwataru, A., Yamada, N., Tsubota, T., Sezutsu, H., Nakagawa, A. Characterization of a diazinon-metabolizing glutathione S-transferase in the silkworm Bombyx more by X-ray crystallography and genie editing analysis. Sci. Rep. 8:16835, 2018. 坂口剛正 D．フィロウイルス科、Ｅ．ブニヤウイルス科、Ｆ．アレナウイルス科 シンプル微生物学 改訂第６版 大熊惠二、堀田博、若宮伸隆編 pp. 311-316. 南江堂 2018年3月発行 ISBN: 978-4-524-25483-5. Yoshida, A., Kawabata, R., Honda, T., Sakai, K., Ami, Y., Sakaguchi, T., and Irie, T. A single amino acid substitution within the paramyxovirus Sendai virus nucleoprotein is a critical determinant for production of IFN-beta-inducing copyback-type defective interfering genomes. J. Virol. 92: e02094-17, 2018, doi: 10.1128/JVI.02094-17. 宮崎直幸、廣瀬未果、常住規代、東浦彰史、中川敦史、岩崎憲治 創薬等ライフサイエンス用クライオ電子顕微鏡単粒子解析支援システム 顕微鏡 53(1):8-12, 2018. 2017Nomura, T., Yoshimoto, R., Kawabata, R., Matsubara, T., Narai, S., Oda, K., Fukushi, M., Irie, T., and Sakaguchi, T. Inactivation of the influenza virus by a supplemental fermented plant product (Manda Koso). Hiroshima Journal of Medical Sciences 66:97-101, 2017. Oda, K., Oda, T., Matoba, Y., Sato, M., Irie, T., and Sakaguchi, T. Structural analysis of the STAT1-STAT2 heterodimer revealed the mechanism of Sendai virus C protein mediated blockade of type 1 interferon signaling. J. Biol. Chem. 292:19752-19766, 2017, doi: 10.1074/jbc.M117.786285. Schock, S. N., Chandra, N. V., Sun, Y., Irie, T., Kitagawa, Y., Gotoh, B., Coscoy, L., and Winoto, A. Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway. Cell Death Differ. 24:615-625, 2017, doi:10.1038/cdd.2016.153. 2016Takenaka, K., Togashi, S., Miyake, R., Sakaguchi, T., and Hide, M. Airborne virus detection by sensing system using a disposable integrated impaction device. Journal of Breath Research 10:036009, 2016. doi:10.1088/1752-7155/10/3/036009. Yumikita, Y., Narita, T., Inoue, Y., Sato, G., Kamitani, W., Oka, T., Katayama, K., Sakaguchi, T., and Tohya, Y. Nonstructural protein p39 of feline calicivirus suppresses host innate immune response by preventing IRF-3 activation. Veterinary Microbiology 185:62-67, 2016, doi:10.1016/j.vetmic.2016.02.005. Hirayama, M., Shibata, H., Imamura, K., Sakaguchi, T., and Hori, K. High-mannose specific lectin and its recombinants from a carrageenophyta Kappaphycus alvarezii represent a potent anti-HIV activity through high-affinity binding to the viral glycoprotein gp120. Marine Biotechnology 18:144-160, 2016. doi:10.1007/s10126-015-9677-1. 2015Oda, K., Matoba, Y., Irie, T., Kawabata, R., Fukushi, M., Sugiyama, M., and Sakaguchi, T. Structural basis of the inhibition of STAT1 activity by Sendai virus C protein. Journal of Virology 89:11487-11499, 2015. Yoshida, A., Kawabata, R., Honda, T., Tomonaga, K., Sakaguchi, T., and Irie, T. IFN-β-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner. Frontiers in Microbiology doi:10.3389/fmicb.2015.00804. Sato, Y., Morimoto, K., Kubo, T., Sakaguchi, T., Nishizono, A., Hirayama, M., and Hori, K. Entry inhibition of influenza viruses with high mannose binding lectin ESA-2 from the red alga Eucheuma serra through the recognition of viral hemagglutinin. Marine Drugs 13:3454-3465, 2015. Latief, M. A., Chikama, T., Ko, J.-A., Kiuchi, Y., Sakaguchi, T., and Obana, A. Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus-type 1 in vitro by photodynamic antimicrobial chemotherapy. Molecular Vision 21:532-537, 2015. Latief, M. A., Chikama, T., Shibasaki, M., Sasaki, T., Ko, J.-A., Kiuchi, Y., Sakaguchi, T., and Obana, A. Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro. Lasers Med. Sci. 30:383-387, 2015. 2014坂口剛正 第６章３節マイナスRNAウイルス 病原微生物学―基礎と臨床 荒川宣親、神谷茂、柳雄介編 pp.186-195. 東京化学同人 ISBN: 978-4-8079-0827-1. 坂口剛正、上田恭子、川端涼子 柿渋でウイルス対策 柿タンニンによる強力なウイルス不活化作用 ニューフードインダストリー 56:17-24, 2014. Matoba, Y., Miyasako, M., Matsuo, K., Oda, K., Noda, M., Higashikawa, F., Kumagai, T., and Sugiyama, M. 1. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS Open Biology 4:834-847, 2014. 坂口剛正 かなり強力！ 柿渋のウイルス退治効果 現代農業 2014年8月 pp. 76-79, 2014. 坂口剛正 柿タンニンによるノロウイルスなどの病原ウイルス不活化 果樹試験研究推進協議会会報 第32号 2014年4月1日発行 pp. 8-12, 2014. Irie, T., Okamoto, I., Yoshida, A., Nagai, Y., and Sakaguchi, T. Sendai virus C proteins regulate viral genome and antigenome synthesis to dictate the negative genome polarity. J. Virol. 88:690-698, 2014. 2013坂口剛正 第28回中国四国ウイルス研究会 ウイルス 63: 249-252, 2013. 二川浩樹、坂口剛正 「新しい固定化抗菌剤の開発とその抗菌・抗ウイルス作用・効果」 抗菌・抗ウイルス材料の開発・評価と加工技術 第１章抗菌・抗ウイルス効果を持つ材料設計と高機能化 第19節 pp. 109-114, 2013年10月発行, 株式会社技術情報協会、東京 ISBN-13: 978-4861044984. Irie, T., Yoshida, A., and Sakaguchi, T. Clustered basic amino acids of the small Sendai virus C protein Y1 are critical to its Ran GTPase-mediated nuclear localization. PLoS One 8:e73740, 2013. Yamaki, M., Shinozaki, K., Sakaguchi, T., Meseck, M., Ebert, O., Ohdan, H., and Woo, S. L. The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer. International Journal of Molecular Medicine 31:299-306, 2013. Ueda, K., Kawabata, R., Irie, T., Nakai, Y., Tohya, Y., and Sakaguchi, T. Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a board range of viruses, PLoS One 8:e55343, 2013. 2012Yoshida, A., Sakaguchi, T., and Irie, T. Passage of a Sendai Virus recombinant in embryonated chicken eggs leads to markedly rapid accumulation of U-to-C transitions in a limited region of the viral genome. PLoS One 7:e49968, 2012.Irie, T., Liu, Y., Drolet, B. S., Carnero, E., Garcia-Sastre, A., and Harty, R. N. In vivo replication and pathogenesis of vesicular stomatitis virus recombinant M40 containing Ebola virus L-domain sequences. Infectious Diseases: Research and Treatment 5:59-64, 2012. Irie, T., Carnero, E., Garcia-Sastre, A., and Harty, R. N. Cytopathogenesis of vesicular stomatitis virus is regulated by the PSAP motif of M protein in a species-dependent manner. Viruses 4:1605-1618, 2012. 坂口剛正（訳）第39章RNAエンベロープウイルス、レビンソン微生物学・免疫学 原書11版、吉開泰信、西山幸廣監訳 丸善出版株式会社 ISBN-13: 978-4621085622. Kong, W.-S., Irie, T., Yoshida, A., Kawabata, R., Kadoi, T., and Sakaguchi, T. Inhibition of virus-like particle release of Sendai virus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2. Hiroshima Journal of Medical Sciences 61:59-67, 2012. Fukushi, M., Yoshinaka, Y., Matsuoka, Y., Hatakeyama, S., Ishizaka, Y., Kirikae, T., Sasazuki, T., and Miyoshi-Akiyama, T. Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus. J. Virol. 86:11745-11753, 2012. Suzuki, N., Fukushi, M., Kosaki, K., Doyle, A. D., de Vega, S., Yoshizaki, K., Akazawa, C., Arikawa-Hirasawa, E., and Yamada, Y. Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS. J. Neurosci. 32:11586-11599, 2012. Fukushi, M., Yamashita, M., Miyoshi-Akiyama, T., Kubo, S., Yamamoto, K., and Kudo, K. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with lethal influenza H1N1 virus. PLoS One 7:e42419, 2012. Kumagai, T., Takagi, K., Koyama, Y., Matoba, Y., Oda, K., Noda, M., and Sugiyama M. Heme protein and hydroxyarginase necessary for biosynthesis of D-cycloserine. Antimicrob. Agents Chemother. 56:3682-3689, 2012. Irie, T., Kiyotani, K., Igarashi, T., Yoshida, A., and Sakaguchi, T. Inhibition of interferon regulatory factor-3 activation by paramyxovirus V protein. J. Virol. 86:7136-7145, 2012. 2011Sakaguchi, T., Irie, T., Kawabata, R., Yoshida, A., Maruyama, H., and Kawakami, H. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation. Neuroscience letters 505:279-281, 2011.Sakaguchi, T., Irie, T., Kuwayama, M., Ueno, T., Yoshida, A., and Kawabata, R. Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5. Microbiology and Immunology 55:760-767, 2011. Karakawa, S., Okada, S., Tsumura, M., Mizoguchi, Y., Ohno, N., Yasunaga, S., Ohtsubo, M., Kawai, T., Nishikomori, R., Sakaguchi, T., Takihara, Y., Kobayashi, M. Decreased expression in Nuclear Factor-κB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency. J. Clin. Immunol. 31:762-772, 2011. Harrison, M. S., Sakaguchi, T., and Schmitt, A. P. Paramyxovirus budding mechanisms, pp. 193-218. In Luo, M. ed., Negative Strand RNA virus. World Scientific, Hackensack, NJ, 2011. Nagai, Y., Takakura, A., Irie, T., Yonemitsu, Y., and Gotoh, B. Sendai virus: Evolution from mouse pathogen to state-of-the-art tool in virus research and biotechnology. In The Biology of Paramyxovirues. Samal, S. K. ed., Caister Academic Press, Norfolk, UK, 2011. （※重要な教科書） 坂口剛正 D．フィロウイルス科、Ｅ．ブニヤウイルス科、Ｆ．アレナウイルス科 シンプル微生物学 改訂第5版 東匡伸、大熊惠二、堀田博編 pp. 297-302. 南江堂 2011年４月発行 ISBN: 978-4-524-26207-6. Kubo, T., Shimose, S., Matsuo, T., Fujimori, J., Sakaguchi, T., Yamaki, M., Shinozaki, K., Woo, S. L., and Ochi M. Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth. J. Orthop. Res. 29:795-800, 2011. 2010Irie, T., Inoue, M., and Sakaguchi, T. Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection. Virology 405:334-341, 2010.Harrison, M. S., Sakaguchi, T., and Schmitt, A. P. Paramyxovirus assembly and budding: building particles that transmit infections. The International Journal of Biochemistry & Cell Biology, 42:1416-1429, 2010. 入江 崇 エンベロープウイルスの粒子形成・出芽機構の解析（杉浦奨励賞受賞論文） ウイルス 60:105-114, 2010. 二川浩樹、柚下香織、平松美菜子、坂口剛正 インフルエンザの拡大リスクを軽減する化合物 ケミカルエンジニアリング 55:41-47, 2010. Irie, T., Nagata, N., Igarashi, T., Okamoto, I., and Sakaguchi, T. Conserved charged amino acids within Sendai virus C protein play multiple roles in the evasion of innate immune responses. PLoS One, 5:e10719, 2010. 2009Nunoya, J., Nakashima, T., Kawana-Tachikawa, A., Kiyotani, K., Ito, Y., Sugimura, K. and Iwamoto, A. Generation of recombinant monoclonal antibodies against an immunodominant HLA-A*2402-restricted HIV type 1 CTL epitope. AIDS Res Hum Retroviruses 25:897-904, 2009.坂口剛正 豚由来新型インフルエンザウイルス（H1N1） 広島医学 62:439-445, 2009. 坂口剛正 研究室紹介 ウイルス 59:115-117, 2009. 加藤 篤、清谷克寛 インターフェロンがセンダイウイルスの病原性発現に及ぼす影響 実験医学 27:1626-1633, 2009. 坂口剛正、入江 崇 パラミクソウイルス感染症 -麻疹・ムンプス・ＲＳウイルス他、病態と予防- 感染防止 19:1-9, 2009. 2008入江 崇 第14回国際ウイルス学会報告参加報告 ウイルス 58:221-222, 2008.Sakaguchi, T., Kato, A., Kiyotani, K., Yoshida, T., and Nagai, Y. Studies on the paramyxovirus accessory genes by reverse genetics in the Sendai virus-mouse system. Proceedings of the Japan Academy, Series B 84:439-451, 2008. Irie, T., Nagata, N., Yoshida, T., and Sakaguchi, T. Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles. Virology 374:495-505, 2008. Shimazu, Y., Takao, S., Irie, T., Kiyotani, K., Yoshida, T., and Sakaguchi, T. Contribution of the leader sequence to homologous viral interference among Sendai virus strains. Virology 372:64-71, 2008. Irie, T., Nagata, N., Yoshida, T., and Sakaguchi, T. Recruitment of Alix/AIP1 to the plasma membrane by the Sendai virus C protein facilitates budding of virus-like particles. Virology 371:108-120, 2008. 2007Nishimura, K., Segawa, H., Goto, T., Morishita, M., Masago, A., Takahashi, H., Ohmiya, Y., Sakaguchi, T., Asada, M., Imamura, T., Shimotono, K., Takayama, K., Yoshida, T., and Nakanishi, M. Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus. J. Biol. Chem. 282:27383-27391, 2007.Irie, T., Carnero, E., Okumura, A., Garcia-Sastre, A., and Harty, R. N. Modifications of the PSAP region of the matrix protein lead to attenuation of vesicular stomatitis virus in vitro and in vivo. J. Gen. Virol. 88:2559-2567, 2007. 入江 崇、坂口剛正 パラミクソウイルスの出芽機構 ウイルス 57:1-8, 2007. 坂口剛正 書評「Fields Virology第５版」 ウイルス 57:115, 2007. Miyoshi, M., Nakano, Y., Sakaguchi, T., Ogi, H., Oda, N., K., Kiyotani, K., Ozono, R., Oshima, T., Yoshida, T., and Chayama, K. Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet. Hypertension Research 30:85-91, 2007. Kato, A., Kiyotani, K., Kubota, T., Yoshida, T., Tashiro, M., and Nagai, Y. Importance of anti-interferon capacity of the Sendai virus C protein for pathogenicity in mice. Journal of Virology 81:3264-3271, 2007. Kiyotani, K., Sakaguchi, T., Kato, A., Nagai, Y., and Yoshida, T. Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice. Virology 359:82-91, 2007. Irie, T., Shimazu, Y., Yoshida, T., and Sakaguchi, T. The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein. J. 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AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding. J. Virol. 79:8933-8941, 2005. Irie, T., and Harty, R. N. L-domain flanking sequences are important for host interactions and efficient budding of VSV recombinants. J. Virol. 79:12617-12622, 2005. Irie, T., and Kawai, A. Further studies on the mechanism of rabies virus neutralization by a viral glycoprotein-specific monoclonal antibody, #1-46-12. Microbiol. Immunol. 49:721-731, 2005. Irie, T., Licata, J. M., and Harty, R. N. Functional characterization of Ebola virus L-domains using VSV recombinants. Virology 336:291-298, 2005. Juozapaitis, M., Slibinskas, R., Staniulis, J., Sakaguchi, T., and Sasnauskas, K. Generation of Sendai virus nucleocapsid-like particles in yeast. Virus Research 108:221-224, 2005. 2004Sugahara, F., Uchiyama, T., Watanabe, H., Shimazu, Y., Kuwayama, M., Fujii, Y., Kiyotani, K., Adachi, A., Kohno, N., Yoshida, T., and Sakaguchi, T. Paramyxovirus Sendai virus-like particle formation by expression of multiple viral proteins and acceleration of its release by C protein. Virology 325:1-10, 2004.Kato, A., Cortese-Grogan, C., Moyer, S. A., Sugahara, F., Sakaguchi, T., Kubota, T., Otsuki, N., Kohase, M., Tashiro, M., and Nagai, Y. Characterization of the amino acid residues of Sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation. J. Virol. 78:7443-7454, 2004. Irie, T., Licata, J. M., Jayakar, H. R., Whitt, M. A., Bell, P., and Harty, R. N. Functional analysis of late-budding domain activity associated with the PSAP motif within the vesicular stomatitis virus M protein. J. Virol. 78:7823-7827, 2004. Irie, T., Licata, J. M., McGettigan, J. P., Schnell, M. J., and Harty, R. N. Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A. J. Virol. 78:2657-2665, 2004. 2003Sakaguchi, T., Kiyotani, K., Watanabe, H., Huang, C., Fukuhara, N., Fujii, Y., Shimazu, Y., Sugahara, F., Nagai, Y., and Yoshida, T. Masking of the contribution of V protein to Sendai virus pathogenesis in an infection model with a highly virulent field isolate. Virology 313:581-587, 2003.吉田哲也、永井美之 ウイルス感染症における臓器特異性 病理と臨床 21:45-56, 2003. Fujii, Y., Goto, H., Watanabe, T., Yoshida, T., and Kawaoka, Y. Selective incorporation of influenza virus RNA segments into virions. Proc. Natl. Acad. Sci., U.S.A. 100:2002-2007, 2003. 藤井 豊、河岡義裕 インフルエンザウイルス：ゲノムRNAのパッケージング 細胞工学 22:438-439, 2003. 2002藤井 豊 香港で発生したH5N1 型インフルエンザウイルスの病原性決定因子 分子呼吸器病 6:484-486, 2002.坂口剛正 抗インフルエンザウイルス薬 カレントテラピー 20:56-59, 2002. Fujii, Y., Sakaguchi, T., Kiyotani, K., Huang, C., Fukuhara, N., and Yoshida, T. Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage. Virus Genes 25:189-193, 2002. Fukuhara, N., Huang, C., Kiyotani, K., Yoshida, T., and Sakaguchi, T. Mutational analysis of the Sendai virus V protein: importance of the conserved residues for Zn binding, virus pathogenesis and efficient RNA editing. Virology 299:172-181, 2002. Fujii, Y., Sakaguchi, T., Kiyotani, K., Huang, C., Fukuhara, N., Egi, Y., and Yoshida, T. Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA. J. Virol. 76:8540-8547, 2002. 藤井 豊、河岡義裕 インフルエンザウイルス・ゲノムのパッケージング ウイルス 52:203-206, 2002. Tanji, H., Yahata, H., Hayamizu, K., Shinozaki, H., Okimoto, T., Sakaguchi, T., and Asahara, T. Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein. Cancer Gene Therapy 9:655-664, 2002. Sakaguchi, T., Uchiyama, T., Huang, C., Fukuhara, N., Kiyotani, K., Nagai, Y., and Yoshida, T. Alteration of Sendai virus morphogenesis and nucleocapsid incorporation by the mutation of cysteine residues of the matrix protein. J. Virol. 76:1682-1690, 2002. Noda, M., Yoshida, T., Sakaguchi, T., Ikeda, Y., Yamaoka, K., and Ogino, T. Molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the 1995 nationalwide outbreak in Japan. J. Clin. Microbiol. 40:140-145, 2002. 2001Sakaguchi, T., Huang, C., Kiyotani, K., and Yoshida, T. Functional divergence of the Paramyxovirinae accessory proteins: the V and C proteins. Recent Research Developments in Virology vol. 3, pp. 341-348, Transworld Network. (ISBN: 81-86846-99-9), 2001.坂口剛正、吉田哲也 エンベロープウイルスのマトリックス蛋白とウイルスの出芽 ウイルス 51:11-19, 2001. Kiyotani, K., Sakaguchi, T., Fujii, Y., and Yoshida, T. Attenuation of a field Sendai virus isolate through egg-passages is associated with the impediment of viral genome amplification in mouse respiratory cells. Arch. Virol. 146:893-908, 2001. Fan, X.-H., Hayamizu, K., Yahata, H., Shinozaki, K., Tashiro, H., Ito, H., Sakaguchi, T., and Asahara, T. Emergence of anti-inflammatory monocytes in long-term surviving host of IL-10-transduced liver allografts. Cytokine 13:183-187, 2001. Fujii, Y., Kiyotani, K., Yoshida, T., and Sakaguchi, T. Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames. Virus Genes 22:47-52, 2001. 2000Eguchi, A., Kondoh, T., Kosaka, H., Suzuki, T., Momota, H., Masago, A., Yoshida, T., Taira, H., Ishii-Watabe, A., Okabe, J., Hu, J., Miura, N., Ueda, S., Suzuki, Y., Taki, T., Hayakawa, T., and Nakanishi, M. Identification of characterization of cell lines with a defect in a post-adsorption stage of Sendai virus-mediated membrane fusion. J. Biol. Chem. 275:17549-17555, 2000.坂口剛正 抗ウイルス薬を中心とした治療 呼吸と循環 48:1127-1131, 2000. Huang, C., Kiyotani, K., Fujii, Y., Fukuhara, N., Kato, A., Nagai, Y., Yoshida, T., and Sakaguchi, T. Involvement of the zinc-binding capacity of Sendai virus V protein in viral pathogenesis. J. Virol. 74:7834-7841, 2000. Shinozaki K, Yahata H, Hayamizu K, Tashiro H, Fan X, Okimoto T, Tanji H, Sakaguchi, T, Ito H, and Asahara T. Adenovirus-mediated allograft transduction of interleukin-10: role in the induction phase of liver allograft acceptance. Transplant Proceedings 32:247-248, 2000. 1999Hu, C. J., Kato, A., Bowman, M. C., Kiyotani, K., Yoshida, T., Moyer, S. A., Nagai, Y., and Gupta, K. C. Role of primary constitutive phosphorylation of Sendai virus P and V proteins in viral replication and pathogenesis. Virology 263:195-208, 1999.Kato, A., Kiyotani, K., Hasan, M. K., Shioda, T., Sakai, Y., Yoshida, T., and Nagai, Y. Sendai virus gene start signals are not equivalent in reinitiation capacity: moderation at the fusion protein gene. J. Virol. 73:9237-9246, 1999. Sakai, Y., Kiyotani, K., Fukumura, M., Asakawa, M., Kato, A., Shioda, T., Yoshida, T., Tanaka, A., Hasegawa, M., and Nagai, Y. Accommodation of foreign genes into the Sendai virus genome: sizes of inserted genes and viral replication. FEBS Lett. 456:221-226, 1999. 坂口剛正 アマンタジンの作用機序 日本医事新報 3940:33-35, 1999. 坂口剛正 学会印象記「第11回国際ウイルス学会」 医学界新聞 2365:2, 1999. Sakaguchi, T., Uchiyama, T., Fujii, Y., Kiyotani, K., Kato, A., Nagai, Y., Kawai, A., and Yoshida, T. Double membrane vesicles released from mammalian cells infected with Sendai virus expressing the matrix protein of vesicular stomatitis virus. Virology 263:230-243, 1999. Takeda, M., Sakaguchi, T., Li, Y., Kobune, F., Kato, A., and Nagai, Y. The genome nucleotide sequence of a contemporary wild strain of measles virus and its comparison with the classical Edmonston strain genome. Virology 256:340-350, 1999. Shinozaki, H., Yahata, H., Tanji, H., Dohi, K., Sakaguchi, T., and Ito, H. Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation. Gene Therapy 6:816-822, 1999. Fujii, Y., Sakaguchi, T., Kiyotani, K., and Yoshida, T. Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases. Microbiol. Immunol. 43:133-140, 1999. 1998Kurotani, A., Kiyotani, K., Kato, A., Shioda, T., Sakai, Y., Mizumoto, K., Yoshida, T., and Nagai, Y. Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis. Genes Cells 3:111-124, 1998.Noma, K., Kiyotani, K., Kouchi, H., Fujii, Y., Egi, Y., Tanaka, K., and Yoshida, T. Endogenous protease-dependent replication of human influenza viruses in two MDCK cell lines. Arch. Virol. 143:1893-1909, 1998. 1997Kato, A., Kiyotani, K., Sakai, Y., Yoshida, T., Shioda, T., and Nagai, Y. Importance of the cysteine-rich carboxyl-terminal half of V protein for Sendai virus pathogenesis. J. Virol. 71:7266-7272, 1997.Kato, A., Kiyotani, K., Sakai, Y., Yoshida, T., and Nagai, Y. The paramyxovirus, Sendai virus, V protein encodes a luxury function required for virus pathogenesis. EMBO J. 16:578-587, 1997. 坂口剛正 ウイルスのイオンチャンネル：インフルエンザウイルスM2蛋白の構造と機能 ウイルス 47:177-186, 1997. 坂口剛正 インフルエンザウイルスM2イオンチャネル−ウイルス増殖のための2つの機能 実験医学 15:2362-2366, 1997. 加藤篤、清谷克寛、坂井（田川）優子 センダイウイルスのエンジニアリング 実験医学 15:2375-2383, 1997. Nagamune, H., Muramatsu, K., Higasine, M., Akamatsu, T., Tamai, Y., Yonetomi, Y., Tsuji, A., Izumi, K., Sakaguchi, T., Yoshida, T., and Matsuda, Y. Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease. In Medical aspects of proteases and protease inhibitors. Katunuma, N., Kido, H., Fritz, H., and Travis, J. eds. (Biomedical and Health Research, Vol. 15) pp. 22-33 (1997), IOS Press, Amsterdam, Netherlands. 坂口剛正 インフルエンザウイルスイオンチャンネル蛋白M2の構造と機能 日本臨床 55:2587-2592, 1997. 坂口剛正、吉田哲也. ウイルスの病原性｛特集「小児の臨床ウイルス学」｝ 小児科診療 60:1727-1734, 1997. Sakaguchi, T., Kiyotani, K., Kato, A., Asakawa, M., Fujii, Y., Nagai, Y., and Yoshida, T. Phosphorylation of the Sendai virus M protein is not essential for virus replication either in vitro or in vivo. Virology 235:360-366, 1997. Sakaguchi, T., Tu, Q., Pinto, L. H., and Lamb, R. A. The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer. Proc. Natl. Acad. Sci., U.S.A. 94:5000-5005, 1997. Takao, S., Kiyotani, K., Sakaguchi, T., Fujii, Y., Seno, M., and Yoshida, T. Protection of mice from respiratory Sendai virus infections by recombinant vaccinia viruses. J. Virol. 71:832-838, 1997. 1996Fukuda, Y., Kimura, A., Hoshino, S., Shintaku, S., Sakaguchi, T., Asahara, T., Sakaki, M., Sumimoto, R., Tashiro, H., Furukawa, M., Ohdan, H., Yoshida, T., and Dohi, K. HLA-DR8 subtyping by polymerase chain reaction (PCR) - DNA conformation polymorphism (DCP) analysis: a simple and practical genotyping method. Hiroshima J. Med. Sci. 45:85-92, 1996.Sakaguchi, T., Leser, G. P., and Lamb, R. A. The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus. J. Cell Biol. 133:733-747, 1996. Inouye, Y., Kanamori, T., Yoshida, T., Koike, T., Shionoya, M., Fujioka, H., and Kimura E. Differential contribution of metal complexation and dimerization to the chemotherapeutic potential of bicyclen-Zn2II complex against human immunodeficiency virus. Biol. Pharm. Bull. 19:456, 1996. 1995Inouye, Y., Fujimoto, Y., Sugiyama, M., Yoshida, T., and Yamase, T. Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity. Biol. Pharm. Bull. 18:996-1000, 1995.Inouye, Y., Kanamori, T., Fujimoto, Y., Sugiyama, M., and Yoshida, T. Novel assay system favorable for the study of cell-to-cell transmission of HIV-1 and its application to the evaluation of anti-HIV drugs. Biol. Pharm. Bull. 18:920-922, 1995. 1994Sakaguchi, T., Fujii, Y., Kiyotani, K., and Yoshida, T. Correlation of proteolytic cleavage of paramyxovirus F protein precursors with expression of the fur, PACE4 and PC6 genes in mammalian cells. J. Gen. Virol. 75:2821-2827, 1994.Ogasawara, T., Emoto, M., Kiyotani, K., Shimokata, K., Yoshida, T., Nagai, Y., and Yoshikai, Y. Sendai virus pneumonia: evidence for the early recruitment of gamma delta T cells during the disease course. J. Virol. 68:4022-4027, 1994. Walker, J. A., Molloy, S. S., Thomas, G., Sakaguchi, T., Yoshida, T., Chambers, T. M., and Kawaoka, Y. Sequence specificity of furin, a proprotein processing endoprotease, for the Hemagglutinin of a virulent avian influenza virus. J. Virol. 68:1213-1218, 1994. 中山隆安、坂口剛正、菊本修、吉田哲也、中村重信 単純ヘルペス脳炎の髄液ＰＣＲ法による早期診断と経過観察 臨床神経学 34:170-173, 1994. Sakaguchi, T., Kiyotani, K., Sakaki, M., Fujii, Y., and Yoshida, T. A field isolate of Sendai virus: Its high virulence to mice and genetic divergence from prototype strains. Arch. Virol. 135:159-164, 1994. Inouye, Y., Kanamori, T., Yoshida, T., Bu, X., Shionoya, M., Koike, T., and Kimura, E. Inhibition of human immunodeficiency virus proliferation by macrocyclic polyamines and their metal complexes. Biol. Pharm. Bull. 17:243-250, 1994. 1993Kiyotani, K., Sakaguchi, T., Fujii, Y., and Yoshida, T. F0-containing noninfectious Sendai virus can initiate replication in the mouse lung but requires a relatively long incubation period. J. Virol. 67:7618-7622, 1993.Kondo, T., Yoshida, T., Miura, N., and Nakanishi, M. Temperature-sensitive phenotype of a mutant Sendai virus strain is caused by its insufficient accumulation of the M protein. J. Biol. Chem. 268:21924-21930, 1993. Inouye, Y., and Yoshida, T. [Polyoxometalate "PM-104" as anti-HIV agent] Nippon Rinsho. 51:186-191, 1993. (in Japanese) Inouye, Y., Tokutake, Y., Yoshida, T., Seto, Y., Hujita, H., Dan, K., Yamamoto, A., Nishiya, S., Yamase, T., and Nakamura, S. In vitro antiviral activity of polyoxomolybdates. Mechanism of inhibitory effect of PM-104 (NH4)12H2(Eu4(MoO4)(H2O)16(Mo7O24)4).13H2O on human immunodeficiency virus type 1. Antiviral Res. 1993 20:317-331, 1993. Sakaguchi, T., Takao, S., Kiyotani, K., Fujii, Y., Nakayama, T., and Yoshida, T. Expression of the HN, F, NP and M proteins of Sendai virus by recombinant vaccinia viruses and their contribution to protective immunity against Sendai virus infections in mice. J. Gen. Virol. 74:479-484, 1993. 1992Walker, J. A., Sakaguchi, T., Matsuda, Y., Yoshida, T., and Kawaoka, Y. Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus. Virology 190:278-287, 1992.Inouye, Y., Tokutake, Y., Kunihara, J., Yoshida, T., Yamase, T., Nakata, A., and Nakamura, S. Suppressive effect of polyoxometalates on the cytopathogenicity of human immunodeficiency virus type 1 (HIV-1) in vitro and their inhibitory activity against HIV-1 reverse transcriptase. Chem. Pharm. Bull. 40:805-807, 1992. Yamanaka, T., Kiyotani, K., Sakaguchi, T., Fukuda, Y., Dohi, K., Yamada, M., Yoshida, M., Nii, S., and Yoshida, T. Detection of cytomegalovirus in urine samples by an enzyme-linked immunosorbent assay using a monoclonal antibody against the viral 150-kilodalton protein. J. Clin. Microbiol. 30:685-690, 1992. Kawahara, N., Yang, X. Z., Sakaguchi, T., Kiyotani, K., Nagai, Y., and Yoshida, T. Distribution and substrate specificity of intracellular proteolytic processing enzyme(s) for paramyxovirus fusion glycoproteins. J. Gen. Virol. 73:583-590, 1992. 吉田哲也、清谷克寛、坂口剛正 研究室で役に立つ細胞株：ウイルス感受性細胞株 生体の科学 43:531-533, 1992. 1991Sakaguchi, T., Matsuda, Y., Kiyokage, R., Kawahara, N., Kiyotani, K., Katunuma, N., Nagai, Y., and Yoshida, T. Identification of endoprotease activity in the trans Golgi membranes of rat liver cells that specifically processes in vitro the fusion glycoprotein precursor of virulent Newcastle disease virus. Virology 184:504-512, 1991.Inouye, Y., Tokutake, Y., Yoshida, T., Yamamoto, A., Yamase, T., and Nakamura, S. Antiviral activity of polyoxomolybdoeuropate PM-104 against human immunodeficiency virus type 1. Chem. Pharm. Bull. 39:1638-1640, 1991. Take, Y., Tokutake, Y., Inouye, Y., Yoshida, T., Yamamoto, A., Yamase, T., and Nakamura, S. Inhibition of proliferation of human immunodeficiency virus type 1 by novel heteropolyoxotungstates in vitro. Antiviral Res. 15:113-124, 1991. 1990Kiyotani, K., Takao, S., Sakaguchi, T., and Yoshida, T. Immediate protection of mice from lethal wild-type Sendai virus (HVJ) infections by a temperature sensitive mutant, HVJpi, possessing homologous interfering capacity. Virology 177:65-74, 1990.Inouye, Y., Take, Y., Tokutake, Y., Yoshida, T., Yamamoto, A., Yamase, T., and Nakamura, S. Inhibition of replication of human immunodeficiency virus by a heteropolyoxotungstate (PM-19). Chem. Pharm. Bull. 38:285-287, 1990. |
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