::2023::

::2022::

::2021::

講演：ウイルス様粒子(VLP)を用いたワクチン開発

演者：竹内 薫 先生 （筑波大学医学医療系生命医科学域環境微生物 准教授）

::2020::

１１月２０日（金）

１１月１３日（金）

１１月６日（金）

１０月２８日（水）

１０月１６日（金）

１０月９日（金）

１０月２日（金）

６月１９日（金）

６月１２日（金）

６月５日（金）

５月２９日（金）

５月２２日（金）

５月１５日（金）

５月８日（金）

５月１日（金）

４月２４日（金）

４月１７日（金）

::2019::

１２月２０日（金）

研究検討会、バイオセーフティ講習会：坂口剛正

１２月１３日（金）

研究検討会：西垣健太

１１月２９日（金）

研究検討会：桝本耀太

１１月２２日（金）

研究検討会：入江 崇
　　　　　　岩田 萌（名古屋大学大学院創薬科学研究科）

１１月１５日（金）

研究検討会：東浦彰史

１０月１１日（金）

研究検討会：野村俊仁

１０月４日（金）

紹介者：福士雅也

Enteroviral infection leads to transactive response DNA-binding protein 43 pathology in vivo.
(Xue, Y. C. et al. The American Journal of Pathology 188:2853-2862, 2018)

９月２７日（金）

研究検討会：小田康祐

１月２１日（月）

紹介者：野村俊仁

Influenza-associated parotitis during the 2014-2015 influenza season in the United States.
(Rolfes, M. A. et al. Clinical Infectious Diseases 67:485-492, 2018)

Non-mumps viral parotitis during the 2014-2015 influenza season in the United States.
(Elbadawi, L. I. et al. Clinical Infectious Diseases 67:493-501, 2018)

１月１７日（木）

紹介者：奈良井清夏

The matrix protein of Nipah virus targets the E3-ubiquitin ligase TRIM6 to inhibit the IKKε kinase-mediated type-I IFN antiviral response.
(Bharaj, P. et al. PLoS Pathogens 12:e1005880, 2016)

１月１１日（金）

紹介者：池田翔太

SHCBP1 is required for midbody organization and cytokinesis completion.
(Abe, E. et al. Cell Cycle 13:2744-2751, 2014)

The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingesstion.
(Abe, E. et al. J. Cell Sci. 126:3263-3270, 2013)

１月７日（月）

紹介者：河崎裕介

Initiation, extention, and termination of RNA synthesis by a paramyxovirus polymerase.
(Jordan, P. C. et al. PLoS Pathogens 14:e1006889, 2018)

::2018::

１２月２１日（金）

紹介者：呑村　顕

Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs.
(Hu, Z. et al. PLOS pathogens 14:e1006948, 2018)

１２月１４日（金）

紹介者：坂口剛正

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.
(Ramanan, V. et al. Scientific Reports 5:10833, 2015)

１２月１２日（水）

講演：Sendai Virus. The Journey from a Mouse Pathogen to a Cutting-edge Biomedical Tool.

演者：永井 美之 先生
（名古屋大学・東京大学名誉教授、理化学研究所名誉研究員、(株)IDファーマ顧問）

１２月７日（金）

紹介者：福士雅也

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62^P392L mutation fo Paget's disease.
(Kurihara, N. et al. Cell Metabolism 13:23-34, 2011)

１１月３０日（金）

紹介者：入江　崇

Mini viral RNAs act as innate immune agonists during influenza virus infection.
(te Velthuis, A. J. W., Fodor, E. et al. Nature Microbiology https://doi.org/10.1038/s41564-018-0240-5, 2018)

１１月２３日（金）

紹介者：松原稔樹

Rab33B controls hepatitis B virus assembly by regulating core membrane association and nucleocapsid processing.
(Bartusch, C, Prange, R. et al. Viruses 9, 157; doi: 10.3390/v9060157.)

１１月１６日（金）

紹介者：小田康祐

EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression.
(Liu, L. et al. Oncogene doi: 10.1038/s41388-018-0473-z. [Epub ahead of print])

１１月２日（金）

紹介者：東浦彰史

Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.
(Sigmund, F. et al. Nat Commun. 9:1990, 2018 doi: 10.1038/s41467-018-04227-3.)

９月１２日（水）

講演：Medusavirusから紐解く巨大ウイルスと生物との関係

演者：武村 政春 先生（東京理科大学）

７月３１日（火）

講演：Three-dimensional imaging of giant viruses

演者：岡本 健太 先生（ウプサラ大学）

２月８日（木）

講演：正二十面体ウイルスの構造決定

演者：東浦 彰史 先生（大阪大学蛋白質研究所 助教）

１月５日（金）

紹介者：佐々木美緒

Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR/Cas9 for efficient gene editing.
(Park, A., Lee, B. et al. Mol. Ther. Methods Clin. Dev. 3:16057, 2016 doi: 10.1038/mtm.2016.57)

::2017::

１２月２２日（金）

紹介者：好澤茉由

Nipah virus C protein recruits Tsg101 to promote the efficient release of virus in an ESCRT-dependent pathway.
(Park, A., Lee, B. et al. PLoS Pathogens 12:e1005659, 2016)

１２月１５日（金）

紹介者：山本祥平

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence.
(Xu, J., Lopez, C. B. et al. Nat. Commun. 8:799, 2017 doi: 10.1038/s41467-017-00909-6)

１２月７日（木）

紹介者：坂口剛正

Preferential transduction of human hepatocytes with lentivirus vectors pseudotyped by Sendai virus F protein.
(Kowolik, C. M. and Yee, J.-K. Molecular Therapy 5:762-769, 2002)

１１月２４日（金）

紹介者：入江　崇

Conserved and host-specific features of influenza virion architecture.
(Hutchinson, E. C., Fodor, E. et al. Nature Commun.5:4816, 2014 doi: 10.1038/ncomms5816.)

１１月１７日（金）

紹介者：小田康祐

A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction.
(Bisson, S. A., Ganem, D. et al. J. Virol. 83:5056-5066, 2009)

１１月１０日（金）

紹介者：松原稔樹

Rab33B and its autophagic Atg5/12/16L1 effector assist in hepatitis B virus naked capsid formation and release.
(Doering T., and Prange, R. Cellular Microbiology 17:747-764, 2015)

１０月２０日（金）

紹介者：野村俊仁

Infection-related microcephaly after the 2015 and 2016 Zika virus outbreaks in Brazil: a surveillance-based analysis.
(de Olibeira, W. K., Schmidt, M. I. et al. Lancet 390:861-870, 2017)

１０月１３日（金）

紹介者：福士雅也

A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection.
(Marchiando, A. M., Cadwell, K. et al. Cell Host & Microbe 14:216-224, 2013)

３月２８日（火）

講演：Stopping a Silent Killer” The Medicinal Chemisty behind the Cure of Hepatitis C Virus Infection

演者：Dr. Kurt Ritter (Sanofi-Aventis GmbH, Frankfurt, Deutschland)

１月２０日（金）

紹介者：夏原啓輝

Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteins.
(Pentecost, M., Lee, B. et al. PLoS Pathog. 11:e1004739, 2015)

１月１３日（金）

紹介者：今薗直博

RIG-I detects mRNA of intracellular Salmonella enterica Serovar Typhimurium during bacterial infection.
(Schmolke, M., Garcia-Sastre, A. et al. mBio 5:e01006-14, 2014)

１月６日（金）

紹介者：章　浩博

PKR transduces MDA5-dependent signals for Type I IFN induction.
(Phem, A. M., Levy, D. E. et al. PLoS Pathog. 12:e1005489, 2016)

::2016::

１２月２２日（木）

紹介者：大嶺孝仁

Replication of human noroviruses in stem cell-derived human enteroids.
(Ettayebi, K., Crawford, S. E., Murakami, K., Estes, M. K. et al. Science 10.1126/science.aaf5211, 2016.)

１２月１６日（金）

紹介者：田中基樹

Viral suppression of innate immunity via spatial isolation of TBK1/IKKe from mitochondrial antiviral platform.
(Ning, Y.-J., Hu, Z., Wang, H. et al. J. Mol. Cell Biol. 6:324-337, 2014.)
Distribution of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies.
(Ning, Y.-J., Wang, H. et al. J. Virol. 89:4227-4236, 2015.)

１２月９日（金）

紹介者：坂口剛正

ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signaling.
(Mercier, V., Sadoul, R. et al. Sci. Rep. 6: 26986, 2016.)

１２月２日（金）

紹介者：入江　崇

Review Seminar: Dynamics of nucleocapsids of negative-sense RNA viruses.

１１月２５日（金）

::2015::

１２月１８日（金）

紹介者：吉山紗代

Regulation of viral RNA synthesis by the V protein of parainfluenza virus 5.
(Yang, Y., He, B. et al. J. Virol. 89: 11845-11857, 2015)

１２月１１日（金）

紹介者：安本圭秀

Aicardi-Goutie`res syndrome is caused by IFIH1 mutations.
(Oda, H., Heike, T. et al. The American Journal of Human Genetics 95: 121-125, 2014)

１２月４日（金）

紹介者：松原稔樹

Involvement of host cellular multivesicular body functions in hepatitis B virus budding.
(Watanabe, T., Ahlquist, P. et al. PNAS 104: 10205-10210, 2015)

１１月２７日（金）

紹介者：原　愛美

Immunostimulatory defective viral genomes from respiratory syncytial virus promote a strong innate antiviral response during infection in mice and humans.
(Sun, Y., Lopez, C. B. et al. PLoS Pathogens 2015 Doi:10.1371/journal.ppat.1005122)

１１月１２日（木）

紹介者：福士雅也

Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten Syndrome.
(Jang, M.-A., Ki, C.-S. et al. The Americal Journal of Human Genetics 96: 266-274, 2015)

１１月６日（金）

紹介者：坂口剛正

The interferon-inducible protein tetherin inhibits hepatitis B virus virion secretion.
(Yan, R., Guoa, H. et al. J. Virol. 89: 9200-9212, 2015)

Identification of BST-2/tetherin induced hepatitis B virus restriction and hepatocyte-specific BST-2 inactivation.
(Lv, M., Yu, X.-F. et al. Scientific Reports 5: 11736, 2015)

Molecular dissection of HBV evasion from restriction factor tetherin: a new perspective for antiviral cell therapy.
(Miyakawa, K., Ryo, A. et al. Oncotarget 6: 21840-21852, 2015)（概略紹介）

１０月２９日（木）

紹介者：入江　崇

Measles virus defective interfering RNAs are generated frequently and early in the absence of C protein and can be destabilized by adenosine deaminase acting on RNA-1-like hypermutations.
(Pfaller, C., K, Cattaneo, R. et al. J. Virol. 89: 7735-7747, 2015)

１０月２３日（金）

紹介者：小田康祐

Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy.
(Liang, B., Whelan, S. P. et al. Cell 162: 314-327, 2015)

７月１４日（火）

講演：Rabies virus tools for understanding structure and function of neural circuits.

演者：小坂田文隆 先生（名古屋大学 大学院創薬科学研究科 神経情報処理研究チーム 講師）

１月２０日（火）

紹介者：益田啓志

FLN26 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
(Sanada, T. et al. J. Biol. Chem. 283: 33858-33864, 2008)

１月１９日（月）

紹介者：谷本将一

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes.
(Feng, Z. et al. Nature 496: 367-371, 2013)

１月１６日（金）

紹介者：見越正札

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.
(Runge, S. et al., PLoS Pathg. 10: e1004081, 2014)

１月１５日（木）

演者：柳野祐輔

アデノ随伴ウイルスのメカニズムを利用した自殺遺伝子搭載 iPS細胞の樹立とその効率向上

１月１４日（水）

紹介者：白河伸介

Morbillivirus control of the interferon response: relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets.
(Svitek, N. et al. J. Virol. 88: 2941-2950, 2013)

１月１３日（火）

紹介者：北島裕也

The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.
(Bruns, A. M. et al. Mol. Cell 55: 771-781, 2014)

::2014::

１２月１８日（木）

紹介者：坂口剛正

Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin.
(Watanabe, R. et al. Virology 417: 50-56, 2011)

Nonlytic viral spread enhanced by autophagy components.
(Bird, S. W. et al. PNAS 111: 13081-13086, 2014)

１２月１２日（金）

紹介者：入江　崇

How do paramyxovirus V proteins interfere triggering of type-I IFN-mediated innate immunity?
(Dr. Takashi Irie's review)

１２月４日（木）

紹介者：小田康祐

STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling.
(Begitt, A. et al. Nat. Immunol. 15: 168-176, 2014)

１２月２日（火）

講演：動物レトロウイルス・ネコモルビリウイルス＊

演者：坂口 翔一 先生（京都大学ウイルス研究所・宮沢研・大学院生）

１１月２７日（木）

紹介者：福士雅也

TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
(Narayan, K. et al. J. Virol. 88: 10748-10757, 2014)

６月２４日（火）

講演：ベトナムにおけるリケッチア症原因菌研究

演者：堀田 こずえ 先生（東京大学大学院農学生命科学研究科・助教）

::2013::

１２月２６日（木）

紹介者：星野羊一

An in-frame deletion in the NS protein-coding sequence of parvovirus H-1PV efficiently stimulates export and infectivity of progeny virions.
(Weiss, N., Salome, N. et al. J. Virol. 86: 7554-7564, 2012)

１２月１２日（木）

紹介者：福士雅也

Tmprss2 is essetial for influenza H1N1 virus pathogenesis in mice.
(Hatesuer, B. et al. PLoS Pathog. 9: e1003774, 2013)

１１月２８日（木）

紹介者：小田康祐

ALIX-CHMP4 interactions in the human ESCRT pathway.
(MaCullough, J., Hill, C P. et al. PNAS 105: 7687-7691, 2008)

１１月１４日（木）

紹介者：入江　崇

Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction. (and others).
(Killip, M. J., Randall, R. E. et al. J. Virol. 87: 4798-4807, 2013)

１０月３１日（木）

紹介者：坂口剛正

Alix regulates egress of hepatitis B virus naked capsid particles in an ESCRT-independent manner.
(Bardens, A., Prange, R. et al. Cellular Microbiology 13: 602-619, 2011)

３月７日（木）

紹介者：星野羊一

A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant.
(Martinez-Gil, L., Palese, P. et al. J. Virol. 87: 1290-1300, 2013)

２月２１日（木）

紹介者：坂口剛正

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.
(Motz, C., Conzelmann, K.-K., Hopfner, K.-P. et al. Science 339: 690-693, 2013)

２月７日（木）

紹介者：小田康祐

Independent structural domains in Paramyxovirus polymerase protein.
(Dochow, M, Plemper, R. K. et al. J. Biol. Chem. 287: 6878-6891, 2012)

::2012::

１２月１９日

紹介者：福士雅也

Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS.
(Suzuki, N., Fukushi, M., Yamada, Y. et al. J. Neurosci. 32: 11586-11599, 2012)

１２月６日

紹介者：吉田明日香

Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase.
(Morin, B., Whelan, S. P. et al. EMBO J. 31: 1320-1329, 2012)

１１月２２日

紹介者：入江　崇

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.
(Onomoto, K., Fujita, T. et al. PLoS One 7: e43031, 2012)

１０月１３日（土）

講演：長崎大学ベトナム感染症研究拠点とそこでの研究＊

演者：堀田こずえ 先生（長崎大学熱帯医学研究所 助教）

５月８日（火）

講演：麻疹ウイルスのアセンブリーおよびウイルス活性化膜結合型プロテアーゼの研究＊

演者：竹田 誠 先生（国立感染症研究所ウイルス第三部 部長）

３月２８日（水）

講演：ラッサウイルスの研究＊

演者：野田岳志 先生（東京大学医科学研究所感染免疫部門ウイルス感染分野 准教授）

３月７日（水）

講演：麻疹ウイルス病原性の研究＊

演者：竹内 薫 先生（筑波大学人間総合科学研究科医学系専攻感染生物学分野 准教授）

::2011::

１２月２２日

紹介者：坂口剛正

Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions.
(Liljeroosa, L., Butchera, S. L. et al. PNAS 108: 18085-18090, 2011)

High mannose-binding lectin with preference for the cluster of alpha1-2-mannose from the green alga Boodlea coacta is a potent entry inhibitor of HIV-1 and influenza viruses.
(Sato, Y., Hori, K. et al. JBC 22: 19446-19458, 2011)

１２月８日

紹介者：入江　崇

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and beta-catenin.
(Zhu, J., Sarkar, S. N. et al. EMBO J. 30: 4838-4849, 2011)

１１月２４日

紹介者：吉田明日香

BST2/Tetherin enhances entry of human cytomegalovirus.
(Viswanathan, K., Flueh, K. et al. PLoS Pathog. 7: e1002332, 2011)

７月２１日

紹介者：Andrea M. Murphy

Ribose 2-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.
(Zuest, R., Thiel, V. et al. Nat. Immunol. 12: 137-144, 2011)

７月１４日

紹介者：坂口剛正

Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.
(Caignard, G., Tangy, F. et al. PLoS Pathog. 5: e1000587, 2009)

７月７日

紹介者：惠木慶子

N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN.
(Londrigan, S. L., Reading, P. C. et al. J. Virol. 85:2990-3000, 2011)

６月３０日

紹介者：入江　崇

Failure to activate the IFN-beta promoter by a paramyxovirus lacking an interferon antagonist.
(Killip, M. J., Randall, R. E. et al. Virology 415:39-46, 2011)

６月２３日

紹介者：吉田明日香

RAB11A is essential for transport of the influenza virus genome to the plasma membrane.
(Eisfeld, A. J., Kawaoka, Y. et al. J. Virol. 85:6117-6126, 2011)

The Rab11 pathway is required for influenza A virus budding and filament formation.
(Bruce, E. A., Stuart, A. D. et al. J. Virol. 84:5848-5859, 2010)

６月９日

紹介者：坂口剛正

Activation of IFN-beta expression by a viral mRNA through RNase L and MDA5.
(Luthra, P., He, B. et al. PNAS 108:2118-2123, 2011)

６月２日

紹介者：惠木慶子

TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
(Pertel, T., Luban, J. et al. Nature 472:361-365, 2011)

５月２６日

紹介者：吉田明日香

Sendai virus induced cytoplasmic actin remodeling correlates with efficient virus particle production.
(Miazza, V., Roux, L. et al. Virology 410:7-16, 2010)

Phosphatidylinositol 3-kinase signaling delays Sendai virus-induced apoptosis by preventing XIAP degradations.
(White, C. L., Sen, G. C. et al. J. Virol. 85:5224-5227, 2011)

５月１９日

紹介者：入江　崇

ALIX/AIP1 is required for NP incorporation into Mopeia virus Z-induced virus-like particles.
(Shtanko, O., Kawaoka, Y. et al. J. Virol. 85:3631-3641, 2011)

::2010::

１２月１６日

紹介者：吉田明日香

Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding.
(Wang, Y. E., Lee, B. et al. PLoS Pathog. 6:e1001186, 2010)

１２月９日

紹介者：惠木慶子

Heterochromatin silencing of p53 target genes by a small viral protein.
(Soria, C., O'Shea, C. C. et al. Nature 466:1076-1081, 2010)

１２月２日

紹介者：上田恭子

ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.
(Zhao, C., Krug, R. M. et al. PNAS 107:2253-2258, 2010)

１１月２５日

紹介者：入江　崇

Influenza virus M2 protein mediates ESCRT-independent membrane scission.
(Rossman, J. S., Lamb, R. A. et al. Cell 142:902-913, 2010)

１１月１８日

紹介者：金村倫太郎

Trafficking of Sendai virus nucleocapsids is mediated by intracellular vesicles.
(Chambers, R., Takimoto, T. PLoS One 5:e10994, 2010)

１１月４日

紹介者：坂口剛正

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing.
(Baum, A., Garcia-Sastre, A. et al. PNAS 107:16303-16308, 2010)

７月２８日、８月３日

紹介者：金村倫太郎

Sendai virus particle production: basic requirements and role of the SYWST motif present in HN cytoplamic tail.
(Gosselin-Grenet, A.-S., Roux, L. et al. Virology 405:439-447, 2010)

７月２２日、３０日

紹介者：上田恭子

Mechanism of adenovirus neutralization by human α-defensins.
(Smith, J. G., Nemerow, G. R. Cell Host&Microbe 3:11-19, 2008)

７月８日、１５日

紹介者：Kong Weng Sheng

Tetherin inhibits HIV-1 release by directly tethering virions to cells.
(Perez-Caballero, D., Bieniasz, P. D. et al. Cell 139:499-511, 2009)

７月１日

紹介者：吉田明日香

An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses.
(DeWitte-Orr, S. J., Mossman, K. L. et al. PLoS Pathog. 6:e100082, 2010)

６月２４日

紹介者：惠木慶子

Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation.
(Karakosiliotis, I., Goodfellow, I. G. et al. PLoS ONE 5:e9562, 2010)

６月１７日

紹介者：入江　崇

Unpaired 5'ppp-nucleotides, as found in Arenavirus double-stranded RNA panhandles, are not recognized by RIG-I.
(Marq, J.-B., Garcin, D. et al. J. Biol. Chem. 285:18208-18216, 2010)

６月１０日

紹介者：清谷克寛

Induction of interferon-stimulated genes by Chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors.
(Chiliveru, S., Paludan, S. R. et al. PLoS ONE 5:e10005, 2010)

６月３日

紹介者：坂口剛正

Optineurin negatively regulates the induction of IFNβ in response to RNA virus infection.
(Mankouri, J., Macdonald, A. et al. PLoS Pathogens 6:e1000778, 2010)

５月２７日

紹介者：金村倫太郎

Budding of Marburgvirus is associated with filopodia.
(Kolesnikova L., Becker, S. et al. Cellular Microbiology 9:939-951, 2007)

５月１３日

紹介者：上田恭子

The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection.
(Hauber, I., Hauber, J. et al. PNAS 22:9033-9038, 2009)

５月６日

紹介者：島津幸枝

Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.
(Koyama, S., Ishii, K. J. et al. Science Translational Medicine 2:25ra24, 2010)

４月２２日

紹介者：Kong Weng Sheng

Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA.
(Zhang, J., Ye, X. et al. J. Gen. Virol. 90:2751-2758, 2009)

４月１５日

紹介者：吉田明日香

Viral apoptosis is induced by IRF-3-mediated activation of Bax.
(Chattopadhyay, S., Sen, G. C. et al. EMBO J. 1 April 2010, doi:10.1038/emboj.2010.50)

３月２５日

紹介者：入江　崇

Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.
(Habjan, M., Weber, F. et al. PLoS One 3(4):e2032, 2008)

３月１８日

紹介者：惠木慶子

Human host factors required for influenza virus replication.
(Koenig, R., Chanda, S. K. et al. Nature 763:813-817, 2010)

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.
(Karlas, A., Meyer, T. F. et al. Nature 763:818-822, 2010)

３月１１日

紹介者：清谷克寛

Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.
(Gitlin, L., Colonna, M. et al. PLoS Pathogens 6:e1000734, 2010)

３月４日

紹介者：坂口剛正

Reassessing conflicting evolutionary histories of the Paramyxoviridae and the origins of respiroviruses with Bayesian multiple phylogenies.
(MaCarthy, A. J. and Goodman, S. J. Infection, Genetics and Evolution 10:97-107, 2010)

Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction.
(Money, V. A., Yeo, R. P. et al. PNAS 106:4441-4446, 2009)

Crystal structure of a nucleocapsid-like necleoprotein-RNA complex of respiratory syncytial virus.
(Tawar, R. G., Rey, F. A. et al. Science 326:1279-1283, 2009)

２月２５日

紹介者：金村倫太郎

Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
(Goutagny, N., Fitzgerald, K. A. et al. J. Immunol. 184:1168-1179, 2010)

紹介者：上田恭子

Antiviral effect of epigallocatechin gallate on enterovirus 71.
(Ho, H.-Y., Chiu, D. T.-Y. et al. J. Agric. Food Chem. 57:6140-6147, 2009)

１月２８日

紹介者：吉田明日香

Residues in the heptad repeat A region of the fusion protein modulate the virulence of Sendai virus in mice.
(Luque, L. E., Portner, A., Russell, C. J. et al. J. Virol. 84:810-821, 2010)

１月２１日

紹介者：惠木慶子

Heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection.
(Kalia, M., Jameel, S. et al. J. Virol. 83:12714-12724, 2009)

１月１４日

紹介者：Kong Weng Sheng

Glycoprotein-dependent acidification of vesicular stomatitis virus enhances release of matrix protein.
(Mire, C. E., Whitt, M. A. et al. J. Virol. 83:12139-121503, 2009)

::2009::

１２月１０日

紹介者：入江　崇

Measles virus circumvents the host interferon response by different actions of the C and V proteins.
(Nakatsu, Y., Takeda, M. et al. J. Virol. 82:8296-8306, 2008)

A highly attenuated measles virus vaccine strain encodes a fully functional C protein.
(Nakatsu, Y., Takeda, M. et al. J. Virol. 83:11996-12001, 2009)

Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cells.
(Ikegami, S., Yanagi, Y. et al. J. Virol. 84:372-379, 2010)

１２月３日

紹介者：清谷克寛

The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection.
(Steinberg, C., Krug, A. et al. Eur. J. Immunol. 39:1007-1018, 2009)

１１月１４日

紹介者：坂口剛正

Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.
(Munster, V. J. et al. Science 325:481-484, 2009)

Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice.
(Maines, T. R. et al. Science 325:484-487, 2009)

１１月５日

紹介者：金村倫太郎

Rho GTPase modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.
(Quinn, K. Chiorini, J. A. et al. J. Virol. 83:10176-10186, 2009)

１０月１５日

紹介者：上田恭子

Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA.
(Takeshita, M., Kataoka, H. et al. J. Biol. Chem. 284:21165-21176, 2009)

１０月８日

紹介者：五十嵐友季

Mechanism of mda-5 inhibition by paramyxovirus V proteins.
(Childs, K. S., Goodbourn, S. et al. J. Virol. 82:1465-1473, 2009)

１０月１日

紹介者：Kong Weng Sheng

AKT1-dependent activation of NF-kB by the L protein of parainfluenza virus 5.
(Luthra, P., He, B. et al. J. Virol. 82:10887-10895, 2009)

９月２４日

紹介者：吉田明日香

The functional impairment of natural killer cells during influenza virus infection.
(Guo, H., Malarkannan, S. et al. Immunol. and Cell Biol. Sep 1. [Epub ahead of print], 2009)

９月１０日

紹介者：島津幸枝

「豚由来H1N1（新型インフルエンザ）のオーストラリアの流行とferretへの感染実験」

７月２３日

紹介者：惠木慶子

Tight junction-associated protein occludin is required for a post-binding step in hepatitis C virus entry and infection.
(Benedicto, I. , Majano, P. L. et al. J. Virol. 83:8012-8020, 2009)

７月１６日

紹介者：清谷克寛

Human PIV-2 recombinant Sendai virus (rSeV) elicits durable immunity and combines with two additional rSeVs to protect against hPIV-1, hPIV-3, and RSV.
(Jones, B., Hurwitz, J. L. et al. Vaccine 27:1848-1857, 2009)

７月９日

紹介者：入江　崇

Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-indepedent pathway.
(Bruce, E. A., Digard, P. et al. Virology on-line, 2009)

７月２日

紹介者：坂口剛正

Mumps virus matrix, fusion, and nucleocapsid proteins cooperate for efficient production of virus-like particles.
(Li, M., Schmitt, A. P. et al. J. Virol. 83:7261-7272, 2009)

６月２５日

紹介者：山口拓洋

Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en.
(Honda, T., Yamashita, M. et al. Bioorg. Med. Chem. Lett. 19:2938-2940, 2009)

６月１８日

紹介者：金村倫太郎

Single-point mutations of the M protein of a measles virus variant obtained from a patient with subacute sclerosing panencephalitis critically affect solubility and subcellular localization of the M protein and cell-free virus production.
(Jiang, D.-P., Hotta, H. et al. Microbes Infect. 11:467-475, 2009)

６月１１日

紹介者：上田恭子

Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus.
(Isaacs, C. E., Hillier, S. et al. Antimicrob. Agents Chemother. 52:962-970, 2008)

６月４日

紹介者：Kong Weng Sheng

Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses.
(Sun, M., He, B. et al. J. Virol. 82:105-114, 2008)

５月２８日

紹介者：吉田明日香

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
(Gack, M. U., Garcia-Sastre, A. et al. Cell Host Microbe. 5:439-449, 2009)

５月２１日

紹介者：五十嵐友季

Human metapneumovirus glycoprotein G inhibits innate immune responses.
(Bao, X., Casola, A. et al. PLoS Pathog. 4:e1000077, 2008)

５月１４日

紹介者：惠木慶子

Incorporation of membrane-bound, mammalian-derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge.
(Herbert, A. S., Roberts, P. C. et al. Virol. J. 6:42, 2009)

４月３０日

紹介者：清谷克寛

Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages.
(How, W., Ho, W.-Z. et al. J. Virol. 83:3834-3842, 2009)

４月２３日

紹介者：入江　崇

Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission.
(Sherer, N. M., Mothes, W. et al. Nat. Cell Biol. 9:414-420, 2007)

紹介者：島津幸枝

Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia.
(Nga, P. T., Morita, K. et al. J. Gen. Virol. 85:1625-1631, 2004)

４月９日

紹介者：坂口剛正

PILRα is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.
(Satoh, T., Arase, H. et al. Cell 132:935-944, 2008)

２月５日

紹介者：惠木慶子

Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 4 and p38 MAPK1.
(Hui, K. P. Y., Peiris, J. S. M. et al. J. Immunol. 182:1088-1098, 2009)

１月２２日

紹介者：入江　崇

Respiratory syncytial virus uses a Vps4-indepedent budding mechanism controlled by Rab11-FIP2.
(Utley, T. J., Crowe, J. E., Jr. et al. PNAS 105:10209-10214, 2008)

::2008::

１２月１８日

紹介者：五十嵐友季

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
(Pfaller, C. K. and Conzelmann, K.-K. J. Virol. 82:12365-12373, 2008)

１２月１１日

紹介者：岡本　巧

Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1.
(Deng, W., Sun, B. et al. J. Biol. Chem. 283:35590-35597, 2008)

１１月２７日

紹介者：坂口剛正

Visualizing the dynamics of viral replication in living cells via Tat peptide delivery of nuclease-resistant molecular beacons.
(Yeh, H.-Y., Chen, W. et al. PNAS 105:17522-17525, 2008)

１１月２０日

紹介者：門井喬浩

Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain.
(Sadzak, I. S., Kovarik, P. et al. PNAS 105:8944-8949, 2008)

１１月１３日

紹介者：惠木慶子

Transport through the Golgi apparatus by rapid partitioning within a two-phase membrane system.
(Patterson, G. H., Lippincott-Schwarts, J. et al. Cell 133:1055-1067, 2008)

１１月６日

紹介者：入江　崇

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.
(Neil, S. J. D., Bieniasz, P. D. et al. Nature 451:425-430, 2008)

１０月１６日

紹介者：五十嵐友季

Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.
(Chakrabarti, A., Williams, B. R. G. et al. J. Biol. Chem. 283:25132-25139, 2008)

１０月９日

紹介者：岡本　巧

Insertion of the two cleavage sites of the respiratory syncytial virus fusion protein in Sendai virus fusion protein leads to enhanced cell-cell fusion and a decreased dependency on the HN attachment protein for activity.
(Rawling, J., Melero, J. A. et al. J. Virol. 82:5986-5998, 2008)

９月２５日

紹介者：坂口剛正

Mechanisms for enveloped virus budding: Can some viruses do without ESCRT?
(Chen, B. J. and Lamb, R. A. Virology 372:221-232, 2008)

９月１８日

紹介者：惠木慶子

Clathrin is a key regulator of basolateral polarity.
(Deborde, S., Rodriguez-Boulan, E. et al. Nature 452:719-723, 2008)

７月１０日

紹介者：門井喬浩

ALIX-CHMP4 interactions in the human ESCRT pathway.
(McCullough, J., Hill, C. P. et al. PNAS 105:7687-7691, 2008)

７月３日

紹介者：入江　崇

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.
(Okumura, A., Harty, R. N. et al. PNAS 105:3974-3979, 2008)

６月２６日

紹介者：五十嵐友季

Influenza A virus abrogates IFN-gamma response in respiratory epithelial cells by disruption of the Jak/Stat pathway.
(Uetani, K. et al. Euro. J. Immunol. 38:1559-1573, 2008)

６月１９日

紹介者：岡本　巧

IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence.
(Peters, K., Sen, G. C. et al. J. Virol. 82:3500-3508, 2008)

６月１２日

紹介者：島津幸枝

Cross-recognition of avian H5N1 influenza virus by human cytotoxic T-lymphocyte populations directed to human influenza A virus.
(Kreijtz, J. H. C. M., Rimmelzwaan, G. F. et al. J. Virol. 82:5161-5166, 2008)

６月５日

紹介者：惠木慶子

Translational control of the innate immune response through IRF-7.
(Makrigiannis, A. P., Sonenberg, N. et al. Nature, 452:323-327, 2008)

５月２９日

紹介者：坂口剛正

Paramyxovirus-induced shutoff of host and viral protein synthesis: role of the P and V proteins in limiting PKR activation.
(Gainey, M. D., Parks, G. D. et al. J. Virol., 82:828-839, 2008)

５月２２日

紹介者：清谷克寛

An important role for type III interferon (IFN-rhambda/IL-28) in TLR-induced antiviral activity.
(Ank, N., Paludan, S. R. et al. J. Immunol., 180:2474-2485, 2008)

５月１５日

紹介者：門井喬浩

Role of endocytosis and cathepsin-mediated activation in Nipah virus entry.
(Diederich, S., Maisner, A. et al. Virology, 2008, in press)

２月２１日

紹介者：入江　崇

De novo synthesis of N and P proteins as a key step in Sendai virus gene expression.
(Wiegand, M. A., Neubert, W. J. et al. J. Virol., 81:13835-13844, 2007)

１月３１日　２月７日

紹介者：島津幸枝　吉田哲也

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin.
(Chandrasekaran, A., Sasisekharan, R. et al. Nature Biotech., 26:107-113, 2008)

１月２４日

紹介者：坂口剛正

Structure and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.
(Fisher, R. D., Sundquist, W. I., Hill, C. P. et al. Cell, 128:841-852, 2007)

１月１０日

紹介者：惠木慶子

Loss of integrin (alpha v beta 8) on dendritic cells causes autoimmunity and colitis in mice.
(Travis, M. A., Sheppard, D. et al. Nature, 449:361-365, 2007)

::2007::

１２月１３日

紹介者：清谷克寛

Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo.
(Ank, N., Paludan, S. R. et al., J. Virol., 80:4501-4509, 2006)

１２月６日

紹介者：門井喬浩

Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and Toll-like receptor 3-triggered signaling pathways.
(Shaw, M. L., Basler, C. F. et al., J. Virol., 79:6078-6088, 2005)

１１月２９日

紹介者：入江　崇

Human immunodeficiency virus type 1 Gag engages the Bro1 domain of Alix/AIP1 through nucleocapsid.
(Popov, S., Gottlinger, G. et al., J. Virol., 2007, Epub)

１１月２８日

講演「Multimerization and Intracellular Trafficking of HIV-1 Gag in Living Cells.」

演者：Dr. Paul W. Spearman (Emory University School of Medicine)

１１月２２日

紹介者：津田光太

Small self-RNA generated by RNase L amplifies antiviral innate immunity.
(Malathi, K., Silverman, R. H. et al., Nature, 448:816-819, 2007)

１１月１５日

紹介者：吉田哲也

AP-3 directs the intracellular trafficking of HIV-1 gag and plays a key role in particle assembly.
(Dong, X., Spearman, P. et al., Cell, 120:663-674, 2005)

１１月８日

紹介者：岡本　功

Virus multiplication and induction of apoptosis by Sendai virus: role of the C proteins.
(Koyoma, A. H. et al., Microbes and Infection, 5:373-378, 2003)

１１月７日

講演「持続感染ウイルスベクター」

演者：西村　健 先生 （産業技術総合研究所、さきがけ）

１１月１日

紹介者：島津幸枝

Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.
(Hatta, M., Kawaoka, Y. et al., PLoS Pathogens, 3:e133, 2007)

１０月１８日

紹介者：高田浩史

Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling.
(Aguliar, H. C., Lee, B. et al., J. Virol., 81:4520-4531, 2007)

１０月１１日

紹介者：惠木慶子

Prion recognition elements govern nucleation, strain specificity and species barriers.
(Tessier, P. M. et al. Nature, 447:556-561, 2007)

９月２７日

演者：坂口剛正

カンファレンスレポート：Workshop on Replication and Cell Biology of Negative Strand RNA Viruses.
Evanston, IL, September 15-19, 2007

７月１９日

紹介者：清谷克寛

Cytokine-independent upregulation of MDA5 in viral infection.
(Yount, J. S. et al. J. Virol., 81:7316-7319, 2007)

７月１２日

紹介者：門井喬浩

Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization.
(Ciancanelli, M. J., Bastler, C. F. J. Virol., 80:12070-12078, 2006)

７月５日

紹介者：津田光太

Role of human b-defensins in HIV infection.
(Weinberg, A. et al. Adv. Dent. Res., 19:42-28, 2006)

６月２８日

紹介者：坂口剛正

Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles.
(Chen, B. J., Lamb, R. A. et al. J. Virol., 81:7111-7123, 2007)

６月２１日

紹介者：吉田哲也

5'-Triphosphate RNA is the ligand for RIG-I.
(Hornung, V., Hartmann, G. et al. Science, 314:994-997, 2006)

６月１４日

紹介者：入江　崇

Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes.
(Fang, Y., Gould, S. J. et al. PLoS Biology, 5:e158, 2007)

６月７日

紹介者：島津幸枝

Genome analysis linking recent European and African influenza (H5N1) viruses.
(Salzberg, S. L. et al. Emerging Infectious Diseases, 13:, 2007)

５月３１日

紹介者：惠木慶子

Novel cell death program leads to neutrophil extracellular traps.
(Fuchs, T. A., Zychlinsky, A. et al. J. Cell Biol., 176:231-241, 2007)

５月２４日

紹介者：門井喬浩

A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L.
(Pager, C. T., Dutch, R. E. et al. Virology, 346:251-490, 2006)

５月１７日

紹介者：津田光太

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.
(Fenner, J. E., Hertzog, P. J. et al. Nature Immunology, 7:33-39, 2006)

Negative regulation of cytokine signaling and immune responses.
(Yoshimura, A. et al. Arthritis Research & Therapy, 7:10-110, 2005)

５月１０日

紹介者：坂口剛正

Sendai virus budding in the course of an infection does not require Alix and VPS4A host factors.
(Grosselin-Grenet, A.-S., Roux, L. et al. Virology, 2007, in press)

４月２６日

紹介者：清谷克寛

Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a perinatal lamb model of respiratory syncytial virus infection.
(Meyerholz, D. K. Viral Immunol. 20:188-196, 2007)

Lung-specific transgenic expression of KC enhances resistance to Klebsiella pneumoniae in mice.
(Tsai, W. C, Standiford, T. J. et al. J. Immunol. 161:2435-2440, 1998)

４月１９日

紹介者：野口千笑

Deamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G.
(Nguyen, D. H., Hu, J. et al. J. Virol. 81:4465-4472, 2007)

４月１２日

紹介者：入江　崇

Targeting of the Sendai virus C protein to the plasma membrane via a peptide-only membrane anchor.
(Marq, J.-B., Kolakofsky, D., Garcin, D. et al. J. Virol. 81:3187-3197, 2007)

４月５日

紹介者：門井喬浩

EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus.
(Negrete, O. A., Lee, B. et al. Nature 436:401-405, 2005)

Two key residues in EphrinB3 are critical for its use as an alternative receptor for Nipah virus.
(Negrete, O. A., Lee, B. et al. PLoS Pathogens 2:e7, 2006)

３月２２日

紹介者：吉田哲也

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
(Lenschow, D. J., Whitining Virgin IV, H. et al. PNAS 104:1371-1376, 2007)

３月８日

紹介者：惠木慶子

Distinct domains of the influenza A virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production.
(McCown, M. F, Peckosz, A. et al. J. Virol. 80:8178-8189, 2006)

２月２２日

紹介者：島津幸枝

Emergence and predominance of an H5N1 influenza variant in China.
(Smith, G. J. D., Guan, Y. et al. PNAS 103:16936-16941, 2006)

２月１５日

紹介者：津田光太

PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.
(Liu, B., Shuai, K. et al. Nature Immunology 5:891-898, 2004)

２月１日

紹介者：坂口剛正

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
(Li, T., Zheng, N. et al. Cell 124:105-117, 2006)

１月２５日

紹介者：清谷克寛

Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice.
(Tumpey, T. M., Basler, C. F. et al. J. Virol. 79:14933-14944, 2005)

１月１８日

紹介者：阿部弘美

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
(Saito, T., Gale Jr., M. et al. PNAS 104:582-587, 2007)

１月１１日

紹介者：入江　崇

Budding of Marburgvirus is associated with filopodia.
(Kolesnikova, L., S. Becker et al. Cellular Microbiology, 2006, on line)

::2006::

１１月１６日

紹介者：吉田哲也

A role for IRF3-dependent RXRa repression in hipatotoxicity associated with viral infections.
(Chow, E. K. et al. J. Exp. Med., 2006, on line)

１１月９日

紹介者：惠木慶子

Hepatitis C virus entry depends on clathrin-mediated endocytosis.
(Blanchard, E. et al. J. Virol. 80:6964-6972, 2006)

１１月２日

紹介者：島津幸枝

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
(de Jong, M. D. et al. Nature Medicine 12:1203-1207, 2006)

１０月１９日

紹介者：野田　衛

Norwalk virus-specific binding to oyster digestive tissues.
(Le Guyader, F. S. et al. Emerging Infectious Diseases 12:931-936, 2006)

Histochemical virus observation in the oyster digestion diverticulum with in situ hybridization method.
(Yamaki, N. et al. Jpn. J. Food Microbiol. 23:21-26, 2006)

７月１３日

紹介者：坂口剛正

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
(Kato, H., Akira, S. et al. nature 441:101-105, 2006)

７月６日

紹介者：清谷克寛

Essential role of IPS-1 in innate immune responses against RNA viruses.
(Kumar, H. et al. J. Exp. Med, 2006)

６月２９日

紹介者：入江　崇

NSV2006 in Spain: A Conference Report.

６月２２日

::2005::

１２月１５日

紹介者：高尾信一

An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in Vero cells and does not alter tissue tropism in hamsters.
(Schickli, J. H. et al. J. Virol. 79:10678-10689, 2005).

１２月１日

紹介者：桑山　勝

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
(Kawai, T. et al. Nature Immunology 6:981-988, 2005).

１１月１０日

紹介者：野田　衛

Replication and packaging of Norwalk virus RNA in cultured mammalian cells.
(Asanaka, M. et al. PNAS 102:10327-10332, 2005).

１０月２０日

紹介者：坂口剛正

Subversion of cellular autophagosomal machinery by RNA viruses.
(Jackson, W. T. et al. PLoS Biology 3:e156, 2005).

１０月１３日

紹介者：渡辺　仁

Mitochondrial cell death suppressors carried by human and murine cytomegalovirus confer resistance to proteasome inhibitor-induced apoptosis.
(McCormick, A. L. et al. Journal of Virology 79:12205-12217, 2005).

９月２９日

紹介者：清谷克寛

ISG15, not just another ubiquitin-like protein.
(Kim, K. I. and Zhang, D.-E. BBRC 307:431-434, 2003).
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.
(Ritchie, K. J. et al. Nature Med. 10:1374-1378, 2004).

９月２２日

紹介者：野口千笑

Cellular APOBEC3G restricts HIV-1 infection in resting CD4⁺ T cells.
(Chiu, Y.-L. et al. Nature 435:108-114, 2005).

９月１５日

第１３回国際ウイルス学会レポート

演者：坂口剛正

９月８日

講演「組換えvesicular stomatitis virusを用いたLドメインの解析」

演者：入江　崇 先生

６月２３日

紹介者：吉田哲也

Conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis.
(Sun, M. et al. Journal of Virology. 78:5068-5078, 2004).
Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene.
(Kang, D. et al. Oncogene 23:1789-1800, 2004).

６月１６日

紹介者：平松　憲

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome.
(Wakita, T. et al. Nature Med. published on line).

６月９日

紹介者：島津幸枝

Passive and active inclusion of host proteins in human immunodeficiency virus type 1 gag particles during budding at the plasma membrane.
(Hammarstedt, M. et al. Journal of Virology. 78:5686-5697, 2004).

６月２日

紹介者：惠木慶子

Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses.
(Yang, Z. et al. PNAS 102:797-801, 2005).

５月２６日

紹介者：高尾信一

Recombinant human metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: Deletion of G yields a promising vaccine candidate.
(Biacchesi, S. et al. Journal of Virology. 78:12877-12887, 2004).

５月１９日

紹介者：桑山　勝

Distinct poly(I:C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
(Li, K. et al. J. Biol. Chem. 280:16739-16747, 2005).

５月１２日

紹介者：野田　衛

Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages.
(Wobus, C. E. et al. PLoS Biology 2(12), 2004).

４月２１日

紹介者：坂口剛正

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
(Yoneyama, M. et al. Nature Immunol. 5:730-737, 2004).

４月１４日

紹介者：渡辺　仁

Mumps virus V protein antagonizes interferon without the complete degradation of STAT1.
(Kubota, T. et al. Journal of Virology. 79: 4451-4459, 2005).

４月７日

紹介者：清谷克寛

Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo.
(Bonville, C. A. et al. Journal of Virology. 78: 7984-7989, 2004).

３月１７日

講演「抗ウイルス機構としてのＢ型肝炎ウイルスの G to A hypermutation」

演者：野口　千笑 先生

３月１０日

紹介者：吉田哲也

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.
(Grandvaux, N. et al. Journal of Virology. 76: 5532-5539, 2002).

２月１７日

紹介者：平松　憲

An in vitro model of hepatitis C virion production.
(Heller, T. et al. PNAS 102:2579-2583, 2005).

２月１０日

紹介者：菅原文博

VP40 octamers are essential for Ebola virus replication.
(Hoenen, T. et al. Journal of Virology. 79:1898-1905, 2005).

２月３日

紹介者：島津幸枝

Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding.
(Blot, V. et al. J. Cell Science 117:2357-2367, 2004).

１月２０日

紹介者：惠木慶子

A role for the immunological synapse in lineage commitment of CD4 lymphocytes.
(Maldonado, R. A. et al. Nature 431:527-532, 2004).

１月１３日

紹介者：高尾信一

Targeted destruction of the HIV-1 coat protein gp41 by a catalytic antibody light chain.
(Hifumi, E. et al. Journal of Immunological Methods 269:283-298, 2002).

::2004::

１２月２日

紹介者：桑山　勝

Activation of TBK1 and IKKepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
(Benjamin, R. et al. Journal of Virology 78:10636-10649, 2004).

１１月１８日

紹介者：野田　衛

Genogroup II noroviruses efficiently bind to heparan sulfate proteoglycan associated with the cellular membrane.
(Tamura, M. et al. Journal of Virology 78:3817-3826, 2004).

１１月１１日

紹介者：坂口剛正

Multivesicular bodies as a platform for formation of the Marburg virus envelope.
(Kolesnikova, L. et al. Journal of Virology 78:12277-12287, 2004).

１１月４日

紹介者：渡辺　仁

Canine distemper virus and measles virus fusion glycoprotein trimers: partial membrane-proximal ectodomain cleavage enhances function.
(von Messling, V. et al. Journal of Virology 78:7894-7903, 2004).

１０月２８日

紹介者：清谷克寛

Does Toll-like receptor 3 play a biological role in virus infections?
(Flavell, R. A. et al. Virology 322:231-238, 2004).

１０月２１日

紹介者：野口千笑

Translation of duck hepatitis B virus reverse transcriptase by ribosomal shunting.
(Sen, N. et al. Journal of Virology 78:11751-11757, 2004).

１０月１４日

紹介者：吉田哲也

C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production.
(Komatsu, T. et al. Virology 325:137-148, 2004).

１０月７日

紹介者：島津幸枝

Mechanism of enveloped RNA virus budding.
(Pornillos, O. et al. Trends in Cell Biology 12:569-579, 2003).

９月３０日

紹介者：菅原文博

Ubiquitous activation of the Nipah virus fusion protein does not require a basic amino acid at the cleavage site.
(Moll, M. et al. Journal of Virology 78:9705-9712, 2004).

７月１５日

紹介者：平松　憲

Regulation of PKR and IRF-1 during hepatitis C virus RNA replication.
(Pflugheber, J. et al. PNAS 99:4650-4655, 2004).

７月８日

紹介者：惠木慶子

Prion infection of epithelial Rovo cells is a polarized event.
(Paquet, S. et al. Journal of Virology 78:7148-7152, 2004).

７月１日

紹介者：高尾信一

Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design.
(MacPhail, M. et al. Journal of General Virology 85:1655-1663, 2004).

６月２４日

演者：坂口剛正

カンファレンスレポート：Workshop on Replication and Cell Biology of Negative Strand RNA Viruses.
Evanston, IL, June 12-16, 2004

６月１７日

紹介者：藤井　豊

Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication.
(Crow, M. et al. Journal of Virology 78:6263-6270, 2004).

６月３日

紹介者：野田　衛

Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: identification of 4 distinct strain-specific patterns.
(Huang, P. et al. Journal of Infectious Diseases 188:19-31, 2003).

５月２７日

紹介者：坂口剛正

Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus.
(Terrence, M. et al. PNAS 101:3166−3171, 2004).

５月２０日

紹介者：桑山　勝

Role of transmembrane domain and cytoplasmic tail amino acid sequences of influenza A virus neuraminidase in raft association and virus budding.
(Barman, S. et al. Journal of Virology. 78:5258-5269, 2004).

５月６日

特別講義「パラミクソウイルス持続感染細胞成立の分子基盤」

三重大学微生物学講座教授 伊藤康彦先生

４月２２日

紹介者：渡辺　仁

Budding of PPxY-containing rhabdoviruses is not dependent on host proteins Tsg101 and Vps4A.
(Irie, T. et al. Journal of Virology. 78:2657-2665, 2004).

４月１５日

紹介者：清谷克寛

Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8.
(Heil, F. et al. Science 303:1526-1529, 2004).

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
(Diebold, S. S. et al. Science 303:1529-1531, 2004).

４月８日

紹介者：野口千笑

DNA deamination mediates innate immunity to retroviral infection.
(Harris, R. S. et al. Cell 113:803-809, 2003).

４月１日

紹介者：吉田哲也

The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway.
(Kolesnikova, L. et al. Journal of Virology. 78:2382-2393, 2004).

３月１８日

紹介者：平松　憲

Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.
(Dansako, H. et al. Virus Res. 97:17-30, 2003).

３月４日

紹介者：島津幸枝

The protein network of HIV budding.
(von Schwedler, U. K. et al. Cell 114:701-713, 2003).

２月２６日

紹介者：菅原文博

The structure and receptor-binding properties of the 1918 influenza hemagglutinin.
(Gamblin, S. J. et al. Science on-line 1093155, 2004).

２月１９日

紹介者：惠木慶子

Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus.
(Wang, X. et al. Nature 424:456-461, 2003).

２月１２日

紹介者：藤井　豊

Chimeric influenza A virus with a functional influenza B virus neuraminidase or hemagglutinin.
(Flandorfer, A. et al. Journal of Virology. 77:9116-9123, 2003).

２月５日

紹介者：桑山　勝

Influenza hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion.
(Takeda, M. et al. PNAS 100:14610-14617, 2003).

１月２９日

紹介者：野田　衛

Mutations within the P2 domain of norovirus capsid affect binding to human histo-blood group antigens: evidence for a binding pocket.
(Tan, M. et al. Journal of Virology. 77:12562-12571, 2003).

１月１５日

講演「新たに急性呼吸器感染症の原因ウイルスと同定された”ヒトメタニューモウイルス”感染症について」

高尾 信一 先生（広島県保健環境センター）

::2003::

１２月１１日

紹介者：坂口剛正

AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.
(Strack, B. et al. Cell 114:689-699, 2003).

１２月４日

紹介者：渡辺　仁

Nedd4 regulates egress of Ebola virus-like particles from host cells.
(Yasuda, J. et al. Journal of Virology. 77:9987-9992, 2003).

１１月２７日

紹介者：清谷克寛

Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus.
(van der Sluijs, K. F. et al. Immunology Letters 89:201-206, 2003).

Involvement of Toll-like receptor 4 in innate immunity to respiratory syncytial virus.
(Haynes, L. M. et al. Journal of Virology. 75:10730-10737, 2003).

１１月２０日

特別講演「有害赤潮プランクトンとウイルスの相互関係−赤潮はなぜ消える？−」

長崎 慶三 先生（水産総合研究センタ−瀬戸内海区水産研究所赤潮環境部赤潮制御研究室長）

１１月１３日

紹介者：大石和佳

A single point mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity.
(Pfeiffer, J. K. et al. PNAS 100:7289-7294, 2003).

１１月６日

紹介者：吉田哲也

The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.
(Basler, C. F. et al. Journal of Virology. 77:7945-7956, 2003).

１０月９日

紹介者：平松　憲

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
(Yamamoto, M. et al. Science 301:640-643, 2003).

１０月２日

紹介者：島津幸枝

The V protein of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta.
(Poole, E. et al. Virology 303, 33-46, 2002).

９月２５日

紹介者：菅原文博

Competition between the Sendai virus N mRNA start site and the genome 3'-end promoter for viral RNA polymerase.
(Le Mercier, P. et al. Journal of Virology. 77, 9147-9155, 2003).

９月１８日

紹介者：松田俊二

Characterization of human class-switched polymeric (immunoglobulin M [IgM] and IgA) anti-human immunodeficiency virus type 1 antibodies 2F5 and 2G12.
(Wolbank, S. et al. Journal of Virology. 77, 4095-4103, 2003).

７月１７日

紹介者：惠木慶子

The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein.
(Sunyach, C. et al. EMBO J 22, 3591-3601, 2003).

７月１０日

紹介者：島津幸枝

Caspase 3 activation is essential for efficient influenza virus propagation.
(Wurzer, W. J. et al. EMBO J 22, 2717-2728, 2003).

７月３日

紹介者：桑山　勝

Activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs) by human dendritic cells infected with an attenuated influenza A virus expressing a CTL epitope derived from the HER-2/neu proto-oncogene.
(Efferson, C. L. et al. Journal of Virology. 77, 7411-7424, 2003).

６月２６日

紹介者：藤井　豊

The NB protein of influenza B virus is not necessary for virus replication in vitro.
(Hatta, M. et al. Journal of Virology. 77, 6050-6054, 2003).

Influenza B virus BM2 protein is an oligomeric integral membrane protein expressed at the cell surface.
(Paterson, R. G. et al. Virology 306, 7-17, 2003).

６月１９日

紹介者：野田　衛

Binding of Norwalk virus-like particles to ABH histo-blood group antigens is blocked by antisera from infected human volunteers or experimentally vaccinated mice.
(Harrington, P. R. et al. Journal of Virology. 76, 12335-12343, 2002).

６月１２日

紹介者：坂口剛正

Synthesis of a novel hepatitis C virus protein by ribosomal frameshift.
(Xu, Z. et al. EMBO J. 20, 3840-3848, 2001).

Hepatitis C virus F protein is a short-lived protein associated with the endoplasmic reticulum.
(Xu, Z. et al. Journal of Virology. 77, 1578-1583, 2003).

Triple decoding of hepatitis C virus RNA by programmed translational frameshifting.
(Choi, J. et al. Mol. Cell. Biol. 23, 1489-1497, 2003).

６月５日

紹介者：渡辺　仁

Restriction of viral replication by mutation of the influenza virus matrix protein.
(Liu, T. et al. Journal of Virology. 76, 13055-13061, 2002).

５月２９日

紹介者：野口千笑

Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids.
(Deres, K. et al. Science 299, 893-896, 2003).

５月２２日

紹介者：清谷克寛

Sendai virus vector-mediated gene transfer of glial cell line-derived neurotrophic factor prevents delayed neuronal death after transient global ischemia in gerbils.
(Shirakura, M. et al. Exp. Anim. 52, 119-127, 2003).

Skeletal muscle regeneration after insulin-like growth factor I gene transfer by recombinant Sendai virus vector.
(Shiotani, A. et al. Gene Therapy 8, 1043-1050, 2003).

５月１５日

紹介者：吉田哲也

Retroviruses have differing requirements for proteasome function in the budding process.
(Ott, D. E. et al. Journal of Virology. 77, 3384-3393, 2003).

Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
(Rota, P. A. et al. Science 300, 1394-1399, 2003).

５月８日

紹介者：平松　憲

Regulation of interferon regulatory factor-3 by hepatitis C virus serine protease.
(Foy, E. et al. Science 300, 1145-1148, 2003).

５月１日

紹介者：島津幸枝

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.
(Wilson, J. A. et al. PNAS, 100, 2783-2788, 2003).

４月２４日

紹介者：菅原文博

Respiratory syncytial virus (RSV) fusion protein subunit F2, not attachment protein G, determines the specificity of RSV infection.
(Schlender, J. et al. Journal of Virology. 77, 4609-4616, 2003).

４月１７日

紹介者：松田俊二

Therapeutic dendritic-cell vaccine for simian AIDS
(Lu, W. et al. Nature Medicine 9, 27-32, 2003).

Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 go120
(Veazey, R. S. et al. Nature Medicine 9, 343-346, 2003).

４月３日

紹介者：惠木慶子

Contribution of human a-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor.*
(Zhang, L. et al. Science 298, 995-1000, 2002).

３月２７日

紹介者：高尾信一

A newly discovered human pneumovirus isolated from young children with respiratory tract disease.
(van den Hoogen, B. G. et al., Nature Medicine, 7, 719-724, 2001).

Characterization of human metapneumoviruses isolated from patients in north America.
(Peret, T. C. T. et al., J. Infect. Dis., 185, 1660-1663, 2002).

３月２０日

紹介者：藤井　豊

Role of the 5'-proximal stem-loop structure of the 5' untranslated region in replication and translation of hepatitis C virus RNA.
(Luo, G. et al., Journal of Virology., 77, 3312-3318, 2003).

３月１３日

紹介者：桑山　勝

Minimum molecular architectures for transcription and replication of the influenza virus.
(Honda, A. et al., PNAS, 99, 13166-13171, 2003).

３月６日

紹介者：野田　衛

Norwalk virus-like particle hemagglutination by binding to H histo-blood group antigens.
(Hutson, A. M. et al., Journal of Virology., 77, 405-415, 2003).

２月２７日

紹介者：坂口剛正

Tsg101: HIV-1's ticket to ride.
(Carter, C. A., Trends in Microbiology, 10, 203-205, 2002).

２月２０日

紹介者：渡辺　仁

Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins.
(Latham, T. et al. Journal of Virology., 75, 6154-6165, 2001).

２月１３日

講演「D-cycloserine産生菌の自己耐性機構と生合成酵素」

野田、川原、高橋 先生

１月２３日

紹介者：清谷克寛

Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees.
(Skiadopoulos, M. H. et al. Virology, 297, 153-160, 2002).

Primary replication of a recombinant Sendai virus vector in macaques.
(Kano, M. et al. J. Gen. Virol., 83, 1377-1386, 2002).

::2002::

１２月１２日

講演「Detection of putative lamivudine-resistant mutations in the YMDD motif of the hepatitis B virus polymerase prior to therapy」

大石 和佳 先生

１２月５日

紹介者：吉田哲也

Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.
(Schubert, U. et al. PNAS, 97, 13057-13062, 2000).

１１月２８日

紹介者：平松　憲

Infection of a human hepatoma cell line by hepatitis B virus.
(Gripon, P. et al. PNAS, 99, 15655-15660, 2002).

１１月２１日

紹介者：島津幸枝

Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis.
(Iseni, F. et al. EMBO J., 19, 5141-5150, 2002).

１１月１４日

紹介者：菅原文博

Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication.
(Li, W. et al. Journal of Virology., 76, 11989-12000, 2002).

１１月７日

紹介者：松田俊二

Contribution of human a-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor.
(Zhang, L. et al. Science 298, 995-1000, 2002).

１０月３１日

紹介者：惠木慶子

Kinetic intermediate in the folding of human prion protein.
(Apetri, A. C. et al., J. Biol. Chem. Sep 27, 2002).

and others

１０月２４日

紹介者：高尾信一

Lethal H5N1 influenza viruses escape host anti-viral cytokine responses.
(Seo, S. H. et al., Nat. Med. 8, 950-954, 2002).

１０月３日

紹介者：藤井　豊

Infectious cDNA clone of the epidemic West Nile virus from New York City.
(Shi, P.-Y. et al., Journal of Virology. 76, 5847-5856, 2002).

９月２６日

紹介者：野田　衛

Norwalk virus binds to histo-blood group antigens present on gastroduodenal epithelial cells of secretor individuals.
(Marionneau, S. et al., Gastroenterology 22, 1967-1977, 2002).

Norwalk virus infection and disease is associated with ABO histo-blood group type.
(Hutson, A. M. et al., J. Infect. Dis. 186, 1335-1337, 2002).

９月１９日

紹介者：坂口剛正

Specific binding of cellular La protein with leader RNA of rinderpest virus is responsible for efficient replication of viral RNA.
(Melkone Subbarao, S., et al, ICV XII abstract, V-1200, 2002).

The PPPY motif of human T-cell leukemia virus type 1 gag protein is required early in the budding process.
(Le Blanc, I., et al. Journal of Virology. 76, 10024-10029, 2002).

Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis.
(Strack, B. et al. Journal of Virology. 76, 5472-5479, 2002).

７月１１日

講演「インフルエンザウイルスRNPの粒子への取り込み機構」（留学中の仕事の報告）

藤井　豊 先生

６月２７日

講演「A host protein interacting with Sendai virus V protein」

黄　誠 先生

６月２４日

特別講演「The mechanism of coronavirus RNA packaging」

牧野 伸治 先生（テキサス大学医学部微生物・免疫学講座）

６月６日

講演「カベオラはウイルス侵入の門戸となるか」

野村 隆士 先生（組織学細胞生物学講座）

５月３０日

紹介者：渡辺　仁

Requirements for budding of paramyxovirus simian virus 5 virus-like particles.
(Schmitt, A. P. et al., Journal of Virology 76, 3952-3964, 2002).

５月２３日

紹介者：清谷克寛

Efficient gene transfer to airway epithelium using recombinant Sendai virus.
(Yonemitsu, Y. et al., Nature Biotechnology 18, 970-973, 2000).

Recombinant Sendai virus-mediated gene transfer to vasculature: a new class of efficient gene transfer to the vascular system.
(Masaki, I. et al., FASEB J. 5, 1294-1296, 2001).

５月７日

紹介者：大石和佳

Cloning and expression of a novel hepatitis B virus-binding protein from HepG2 cells.
(de Falco, S. et al., J. Biol. Chem. 276, 36613-36623, 2001).

４月２５日

紹介者：吉田哲也

In vivo interference of Rous sarcoma virus budding by cis expression of a WW domain.
(Patnaik, A. and Wills, J. W. Journal of Virology. 76, 2789-2795, 2002).

４月１８日

紹介者：島津幸枝

Transcription of vesicular stomatitis virus is required to shut off cellular RNA synthesis.
(Weck, P. K. and Wagner, R. R. Journal of Virology. 30, 410-413, 1979).

Use of UV irradiation to identify the genetic information of vesicular stomatitis virus responsible for shutting off cellular RNA synthesis.
(Weck, P. K. et al. Journal of Virology. 30, 746-753, 1979).

４月１１日

紹介者：菅原文博

Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease.
(Fernandez, M. et al. Journal of Virology. 76, 895-904, 2002).

４月４日

紹介者：松田俊二

Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes.
(Chen, X. et al. Nature Medicine 11, 1225-1231, 2001).

３月２８日

紹介者：惠木慶子

Killing activity of neutrophils is mediated through activation of proteases by K+ flux.
(Reeves, E. P. et al. Nature 416, 291-297, 2002).

３月１４日

紹介者：高尾信一

Influenza A (H1N2) viruses identified.
(Web pages, Medline)

３月７日

紹介者：野田　衛

Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.
(Heppner, F. L. et al., Science, 294, 178-182, 2001)

２月２８日

紹介者：坂口剛正

A novel influenza A virus mitochondrial protein that induces cell death.
(Chen, W. et al., Nature Medicine, 7, 1306-1312, 2001)

２月２１日

紹介者：黄　誠

Degradation of STAT1 and STAT2 by the V proteins of Simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferons.
(Andrejeva, J. et al., Journal of Virology., 76, 2159-2167, 2002)

２月１４日

紹介者：福原徳子

The virus-chaperone connection (mini review).
(Sullivan, C. S. and Pipas, J. M. Virology, 287, 1-8, 2001)

２月７日

紹介者：渡辺 仁

Influenza A virus M2 ion channel activity is essential for efficient replication in tissue culture.
(Takeda, M. et al. Journal of Virology. 76, 1391-1399, 2002)

１月３１日

紹介者：清谷克寛

Tumor necrosis factor alpha exerts powerful anti-influenza virus effects in lung epithelial cells.
(Heui Seo, Sang and R. G. Webster Journal of Virology. 376, 1071-1076, 2002)

Characterization of a porcine lung epithelial cell line suitable for influenza virus studies.
(Heui Seo, Sang et al. Journal of Virology. 75, 9517-9525, 2002)

１月２４日

紹介者：大石和佳

Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo.
(Seigneres, B. et al. Journal of Hepatology 34, 114-122, 2001)

１月１７日

紹介者：吉田哲也

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding.
(Garrus, J. E. et al. Cell 107, 55-65, 2001)

１月１０日

特別講演「炭疽とバイオテロ」

桑原 正彦 先生（広島県立病院呼吸器科部長）

::2001::

１２月１３日

忘年会

ひさご

１２月６日

紹介者：島津幸枝

The short Sendai virus leader region controls induction of programmed cell death.
(Garcin, D. et al. Virology 243, 340-363, 1998)

１１月２９日

紹介者：菅原文博

The 5' terminal trailer region of vesicular stomatitis virus contains a position-dependent cis-acting signal for assembly of RNA into infectious particles.
(Whelan, S. P. J. and Wertz, G. W. Journal of Virology. 73, 307-315, 2001)

１１月２２日

紹介者：惠木慶子

The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein.
(Gauczynski, S. et al. EMBO J. 20, 5863-5875, 2001)

１１月１５日

紹介者：松田俊二

An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants.
(Rose, N. F. et al. Cell 106, 539-549, 2001)

１１月８日

紹介者：高尾信一

Comparative analysis of evolutionary mechanisms of the hemagglutinin and three internal protein genes of influenza B virus: multiple cocirculating lineages and frequent reassortant of the NP, M and NS genes.
(Lindstrom, S. E. et al. Journal of Virology. 73, 4413-4426, 1999)

１１月１日

紹介者：野田 衛

Deletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoform.
(Vorberg, I. et al. Journal of Virology. 75, 10024-10032, 2001)

Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jacob disease in humans.
(Race, R. et al. Journal of Virology. 75, 10106-10112, 2001)

１０月２５日

紹介者：坂口剛正

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.
(Hatta, M. et al. Science 293, 1840-1842, 2001)

Recombination in the Hemagglutinin gene of the 1918 Spanish Flu.
(Gibbs, M. J. et al. Science 193, 1842-1845, 2001)

１０月１８日

特別講義「パラミクソウイルスの研究」

三重大学微生物学講座教授 伊藤康彦先生

１０月１１日

紹介者：黄 誠

The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription.
(Parisien, J.-P. et al. Virology 283, 230-239, 2001)

１０月４日

紹介者：福原徳子

Junction adhesion molecule is a receptor for reovirus.
(Barton, E. S. et al. Cell 104, 441-451, 2001)

９月２７日

紹介者：渡辺 仁

The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity.
(von Messling et al. Journal of Virology. 75, 6418-6427, 2001)

９月２０日

紹介者：清谷克寛

Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates.
(Lin, Y. P. et al. PNAS, USA. 97, 9654-9658, 2000)

H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity.
(Matrosovich, M. N. et al. Virology 281, 156-162, 2001)

９月１３日

紹介者：大畠俊之

Exposure of hepatitis C virus (HCV) RNA-positive recipients to HCV RNA-positive blood donors results in rapid predominance of a single donor strain and exclusion and/or suppression of the recipient strain.
(Journal of Virology. 75, 2059-2066, 2001)

９月６日

紹介者：吉田哲也

Mutations in Domain V of the Sendai virus L protein uncouple transcription and replication and differently affect replication in vitro and in vivo.
(Cortese, C. K. et al. Virology 277, 387-396, 2001)